ArticleAmerican journal of physiology. Cell physiology2023
A biologically validated mathematical model for decoding epithelial apical, basolateral, and paracellular electrical properties.
Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- miR-221-3p mediates endothelial injury and predicts cerebral ischemic in carotid artery stenosis.Journal of thrombosis and thrombolysis · 2026Article
- Sub-second extracellular impedance measurement of epithelial cell monolayers using step excitations and time-domain analysis.Scientific reports · 2026Article
- Membrane-resolved epithelial electrophysiology revealed using extracellular electrochemical impedance spectroscopy (EEIS).bioRxiv : the preprint server for biology · 2026Article
- Method for Extracellular Electrochemical Impedance Spectroscopy on Epithelial Cell Monolayers.Bio-protocol · 2025Article
- Method for Extracellular Electrochemical Impedance Spectroscopy on Epithelia.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Epithelial tissues form selective barriers to ions, nutrients, waste products, and infectious agents throughout the body. Damage to these barriers is associated with conditions such as celiac disease, cystic fibrosis, diabetes, and age-related macular degeneration. Conventional electrophysiology measurements like transepithelial resistance can quantify epithelial tissue maturity and barrier integrity but are limited in differentiating between apical, basolateral, and paracellular transport pathways. To overcome this limitation, a combination of mathematical modeling, stem cell biology, and cell physiology led to the development of 3 P-EIS, a novel mathematical model and measurement technique. 3 P-EIS employs an intracellular pipette and extracellular electrochemical impedance spectroscopy to accurately measure membrane-specific properties of epithelia, without the constraints of prior models. 3 P-EIS was validated using electronic circuit models of epithelia with known resistances and capacitances, confirming a median error of 19% (interquartile range: 14%-26%) for paracellular and transcellular resistances and capacitances (
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