Evidence map›Paper›PMID 37899638›Full record

ReviewPediatric transplantation2023

Review of pediatric combined heart-liver transplantation: A roadmap to success.

Jason T C Lee, Deepika Sarode, Juliet A Emamaullee

Open access · hybridAbstract readReview
In one paragraph

Review in Pediatric transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jason T C LeeDivision of Abdominal Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8681-8257
Deepika SarodeDivision of Abdominal Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8883-8462
Juliet A EmamaulleeDivision of Abdominal Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-4238-3057
University of Southern California · US

Funding

Immunologic Biomarkers of Rejection in Clinical Liver TransplantationK08CA245220 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EMAMAULLEE, JULIET · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA245220
6 · The paper itself

Abstract

backgroundCombined heart-liver transplantation (CHLT) is a promising technique to address end stage organ failure in patients with concomitant heart failure and chronic liver disease. While most experience with CHLT has involved adult patients, the expanding population of children born with univentricular congenital heart disease who underwent the Fontan procedure and develop Fontan-associated liver disease (FALD) has emerged as a growing indication for pediatric CHLT.

methodsCurrently, CHLT is performed at a select subset of experienced transplant centers, especially in the pediatric population.

resultsWhile technically demanding, CHLT may offer survival benefit when compared to heart transplant alone with decreased rejection of both synchronous allografts and equivalent outcomes with respect to waitlist time and post-operative complications. Limitations in the technique can be attributed to need for an appropriate multidisciplinary care center, challenges with donor organ availability and allocation, and the complexity associated with patient selection and peri-operative management.

conclusionIn this review, we summarize the history of CHLT, discuss patient selection, and highlight key facets of peri-operative care in the pediatric population.

Indexed as

Heart FailureHeart TransplantationLiver DiseasesLiver TransplantationAdultChildHumansPostoperative ComplicationsRetrospective Studiesliver transplantpediatric heart transplant

Identifiers

PMID37899638
PMCPMC10842164
OpenAlexW4388014115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.