Trial reportBMC oral health2023
Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial.
Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Trial
- Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Review
- Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2026Review
- Long-term effects of a bony mucoperiosteal flap on bone preservation in bony impacted upper third molar surgery: a prospective exploratory study.BMC oral health · 2026Article
- Optimising Outcomes in Endodontic Microsurgery: Evidence, Uncertainties and Future Directions.International endodontic journal · 2026Review
- Different Approaches to the Treatment of Radicular and Related Cysts Associated with Nasal Mucosa in the Maxilla: A Case Series.Journal of clinical medicine · 2026Article
- Two-dimensional and three-dimensional evaluation of bone regeneration using platelet-rich fibrin versus bone putty in large periapical lesions after endodontic surgery: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Two- and three-dimensional evaluation of endodontic microsurgery outcomes in maxillary anterior teeth with through-and-through lesions: a retrospective cohort study.BMC oral health · 2026Article
- Will L-PRF Be the Future of Endodontic Microsurgery? A Series of Case Reports.Clinical and experimental dental research · 2025Article
- Autologous Growth Factor-Rich Concentrate (GFC) Injection in Non-union of Fractures: A Quasi-experimental Study.Indian journal of orthopaedics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery.
methodsEighteen patients with an isolated periapical lesion < 10 mm in the maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect at postoperative one week, three months, and six months was evaluated using cone-beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal-Wallis test and post-hoc Mann-Whitney U test with Bonferroni correction.
resultsAt the three-month follow-up, the PRF and CGF groups showed significantly greater bone healing compared with the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups.
conclusionsThese results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.