Evidence map›Paper›PMID 37899137›Full record

ArticleBMJ open ophthalmology2023

Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study.

Takashi Nishida, Eleonora Micheletti, Kareem Latif, Kelvin H Du, Robert N Weinreb, Sasan Moghimi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00221897 recruitingnot on this map

Diagnostic Innovations in Glaucoma Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2030Enrolled3,000ConditionsPrimary Open Angle Glaucoma, Myopia
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Takashi NishidaDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA.
Eleonora MichelettiDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA.
Kareem LatifDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA.ORCID 0000-0002-2417-7981
Kelvin H DuDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA.
Robert N WeinrebDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA.
Sasan MoghimiDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, California, USA sasanimii@yahoo.com.ORCID 0000-0002-9375-4711

Funding

xADAGES III: Contribution of genotype to glaucoma phenotype in African AmericansR01EY023704 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROTTER, JEROME I, WEINREB, ROBERT N · 2013 to 2017
$6.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
NEI NIH HHS R01 EY023704NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034148
6 · The paper itself

Abstract

objectiveTo investigate the effect of smoking on choroidal microvasculature dropout (MvD) in glaucoma.

designCross-sectional study.

settingTertiary glaucoma centre.

participants223 eyes of 163 patients with primary open-angle glaucoma who had undergone imaging with optical coherence tomography angiography and completed a questionnaire on smoking from the Diagnostic Innovations in Glaucoma Study. PRIMARY OUTCOME MEASURES: Linear mixed-effects models were used to determine the effect of each parameter on MvD area and angular circumference. The sensitivity analysis was performed by categorising the glaucoma severity determined by visual field mean deviation (MD).

resultsMvD was found in 37 (51.4%) eyes with smoking history and in 67 (44.4%) eyes with non-smokers (p=0.389). Larger MvD area and wider angular circumference were found in smokers compared with non-smokers (p=0.068 and p=0.046, respectively). In a multivariable model, smoking intensity was significantly associated with MvD area (0.30(95% CI 0.01 to 0.60) each 0.01 mm

conclusionsSmoking intensity was associated with larger choroidal MvD area in eyes with glaucoma, especially in patients with more severe disease. TRIAL REGISTRATION NUMBER: NCT00221897.

Indexed as

Glaucoma, Open-AngleOptic DiskCross-Sectional StudiesHumansIntraocular PressureMicrovesselsSmokingGlaucomaImaging

Identifiers

PMID37899137
PMCPMC10619022
OpenAlexW4388034639

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.