ArticleDigestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society2024
Pilot study on anti-reflux mucoplasty: Advancing endoscopic anti-reflux therapy for gastroesophageal reflux disease.
Article in Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Clinical Utility of Anti-reflux Mucosal Intervention for Refractory Gastroesophageal Reflux Disease in Patients With a Hiatal Hernia.DEN open · 2027Article
- Changes in endoscopic pressure study integrated system (EPSIS) parameters after antireflux surgery and their association with postoperative clinical outcomes.Surgical endoscopy · 2026Article
- A pilot study on anti-reflux mucoplasty with valve as novel endoscopic therapy for gastroesophageal reflux disease.DEN open · 2026Article
- Targeted Endoscopic Therapies for Gastro-Esophageal Reflux Disease (GERD): A Narrative Review.Journal of personalized medicine · 2026Review
- Feasibility of Endoscopic Closure Method Using Low Cost Clips With Thread for Post Gastric Endoscopic Submucosal Dissection: A Pilot Study.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Endoscopic antireflux mucoplasty using the reopenable-clip over-the-line method for refractory gastro-esophageal reflux disease.Endoscopy · 2025Article
- Antireflux mucoplasty with the reopenable clip-over-the-line method for refractory gastroesophageal reflux disease.Endoscopy · 2025Article
- Application status of endoscopic anti-reflux mucosal interventions in the treatment of gastroesophageal reflux disease.World journal of gastrointestinal surgery · 2025Review
- Redefining endoscopic management of refractory gastroesophageal reflux disease: the role of Stretta radiofrequency therapy and antireflux mucosectomy.Clinical endoscopy · 2025Article
- Endoscopic resection for gastric submucosal tumors: A single-center experience in Japan.DEN open · 2025Article
- Phase concept: Novel dynamic endoscopic assessment of intramural antireflux mechanisms (with video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Development and Application of Endoscopic Antireflux Mucosectomy in Treating Refractory Gastroesophageal Reflux Disease.Gastroenterology research and practice · 2025Review
- Refractory Gastroesophageal Reflux Disease Successfully Treated with Endoscopic Anti-gastroesophageal Reflux Mucosal Resection by the ESD-G Method (with Video).Internal medicine (Tokyo, Japan) · 2024Article
- Introducing antireflux mucoplasty with valve: a novel endoscopic treatment for GERD.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Closure in antireflux mucoplasty using anchor prong clips: dead space-eliminating technique.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Cap-EMR Ⅱ.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Enhancing closure efficacy in antireflux mucoplasty through endoscopic hand-suturing technique.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAnti-reflux mucosectomy (ARMS) and anti-reflux mucosal ablation (ARMA) were developed as interventions for proton pump inhibitor (PPI)-refractory/-dependent gastroesophageal reflux disease (GERD). Although ARMS and ARMA are established treatments for PPI-refractory GERD, reliance on natural healing for ulcer scar formation introduces uncertainty and bleeding risk. To address these issues, we introduced a novel approach called anti-reflux mucoplasty (ARM-P), which involves immediate closure of mucosal defects following mucosectomy. This pilot study aims to evaluate the safety, feasibility, and efficacy of ARM-P.
methodsA retrospective single-center study was conducted using prospectively collected data from October 2022 to July 2023. Patients with PPI-refractory/-dependent GERD who underwent ARM-P were included. The study evaluated technical success of ARM-P, before and after ARM-P GERD-Health Related Quality of Life Questionnaire, GerdQ, and Frequency Scale for the Symptoms of GERD scores, along with PPI discontinuation and endoscopic esophagogastric junction morphology.
resultsA total of 20 patients with a median age of 61.5 years underwent the ARM-P procedure. The procedure achieved 100% technical success without adverse events. After ARM-P, 55.0% discontinued PPI usage and 15.0% reduced PPI dose by half. Median GERD-Health Related Quality of Life Questionnaire score improved from 21 to 6 (P = 0.0026), median GerdQ score improved from 9 to 7 (P = 0.0022), and median Frequency Scale for the Symptoms of GERD score decreased from 16 to 7 (P = 0.0003). Median Hill's Classification significantly improved from grade III to grade I (P = 0.0001).
conclusionsThis study presents the first pilot report of ARM-P, demonstrating its procedural safety, technical feasibility, and short-term efficacy.
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