Observational studyRespiration; international review of thoracic diseases2023
Tuberculosis Case Detection and Guideline Adherence among Child Contacts in Switzerland: A Retrospective Observational Study.
Observational study in Respiration; international review of thoracic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Determinants of tuberculosis infection and disease in paediatric patients in the Czech Republic after tuberculosis exposure.International health · 2026Article
- Latent transition analysis of stigma and its association with treatment adherence in pulmonary tuberculosis patients during anti-tuberculosis therapy.Frontiers in public health · 2026Article
- Tuberculosis contact investigation: an evaluation of yield and guideline adherence, Upper Bavaria, Germany, 2018 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Tic Cough in an Adolescent with Organic Brain Pathology-A Case Report and Literature Review.Brain sciences · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren exposed to a tuberculosis (TB) index case are at risk of TB infection and disease.
objectivesThe aim of this study was to describe the proportion of child contacts who developed TB infection or disease after exposure and to assess the diagnostic pathways and adherence to current guidelines.
methodsRetrospective observational study including children ≤16 years of age who had contact to a TB index case between January 2019 and July 2021. Analysis was stratified by age groups 0-4, 5-11, and 12-16 years.
resultsOf 401 TB-exposed children, data were available for 380 (95%). Of those, 7 (2%) were diagnosed with TB disease and 35 (9%) with TB infection. We identified several deviations in the management compared to recommendations in national Swiss guidelines: In the children aged 0-4 years, only 82% were examined with an immunodiagnostic test or a chest radiography within 2 weeks after last contact. Recommended prophylactic treatment was prescribed in 66% of the children only. In the children aged 5-11 years, 64% were tested with an immunodiagnostic test in a first examination and 75% in a second examination, 2 weeks and 2 months after last contact, respectively.
conclusionsContact investigations of children exposed to a TB index case identified a significant proportion of children with TB infection and disease in a low TB incidence setting. We observed significant deviations from the guidelines in the contact investigations suggesting the need for improved implementation.
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