Evidence map›Paper›PMID 37898989›Full record

ArticleArchives of microbiology2023

Effect of embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii.

Usman Ahmed, Seng-Kai Ong, Khalid Mohammed Khan, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Mohd Farooq Shaikh, Bader Saleem Alawfi, Ayaz Anwar

Abstract read
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In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Usman AhmedDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500, Selangor, Malaysia.
Seng-Kai OngDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500, Selangor, Malaysia.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Ruqaiyyah SiddiquiMicrobiota Research Center, Istinye University, 34010, Istanbul, Turkey.
Naveed Ahmed KhanMicrobiota Research Center, Istinye University, 34010, Istanbul, Turkey. naveed5438@gmail.com.
Mohd Farooq ShaikhNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500, Bandar Sunway, Malaysia.
Bader Saleem AlawfiDepartment of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, 42353, Madinah, Saudi Arabia.
Ayaz AnwarDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500, Selangor, Malaysia. ayazanwarkk@yahoo.com.
Sunway University · MYIstinye University · TRCharles Sturt University · AUInternational Center for Chemical and Biological Sciences · PKTaibah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acanthamoeba castellanii is the causative agent of fatal encephalitis and blinding keratitis. Current therapies remain a challenge, hence there is a need to search for new therapeutics. Here, we tested embelin (EMB) and silver nanoparticles doped with embelin (EMB-AgNPs) against A. castellanii. Using amoebicidal assays, the results revealed that both compounds inhibited the viability of Acanthamoeba, having an IC

Indexed as

Acanthamoeba castellaniiMetal NanoparticlesApoptosisBenzoquinonesSilverBenzoquinonesembelinSilverA. castellaniiAnti-amoebicApoptosisEmbelinSilver nanoparticles coated with embelinTranscriptome analysis

Identifiers

PMID37898989
OpenAlexW4388011530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.