Evidence map›Paper›PMID 37898858›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Genetic Polymorphism in FSCN1 rs3801004 C/G and CD44 rs353639 A/C, as Prognostic Factor in Egyptian Breast Cancer Patients.

Noha E Ibrahim, Reham Mohammad Raafat Hamed, Ahmed Refaat, Yasser O Mosaad, Dina Mohamed Mekawy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Noha E IbrahimDepartment of Microbial Biotechnology, Biotechnology Research Institute, National Research Centre (NRC), 33 El-Behouth St., Dokki, Giza, P.O. 12622, Egypt.ORCID 0000-0002-7176-4687
Reham Mohammad Raafat HamedDepartment of Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt.ORCID 0000-0002-5526-2134
Ahmed RefaatDepartment of General Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt.
Yasser O MosaadDepartment of Pharmacy Practice & Clinical Pharmacy, Future University, Egypt.ORCID 0000-0003-2566-5183
Dina Mohamed MekawyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-4364-9400
Cairo University · EGBadr University in Cairo · EGFuture University in Egypt · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne of the main causes of cancer-related deaths is breast cancer. Fascin-1(FSCN1) is an actin-binding protein that is present in the mesenchymal, neuronal, and endothelial cells of mammals. Patients with breast cancer have been found to have FSCN1 overexpression. CD44 is crucial for the development, invasion, and tumour spread. Therefore, we aimed to investigate the role of FSCN1&CD44 gene polymorphisms in breast cancer (BC) risk and prognosis. MATERIALS &

methodsA total of 96 BC patients and 50 controls were included in the case-control study for risk prediction. We examined the association between The SNPs on FSCN1(rs3801004) and CD44(rs353639) and BC susceptibility and clinicopathological features using a real-time PCR in a cohort of the Egyptian population.  Results: A significant association of both SNPs on FSCN1(rs3801004)C allele and CD44(rs353639)A allele and BC susceptibility(adjusted OR=4.38,95%CI:2.6-7.4,p<0.001, and adjusted OR=4.44,95%CI:2.65-7.44,p <0.001,respectively). Moreover, CC genotype in FSCN1(rs3801004) were likely to progress to developing G2&G3 and N2&N3 and stage II & stage IV, according to the TNM staging and GG+GC genotypes increased within individuals who had a positive family history of BC. Individuals who carry at least one A allele for CD44rs353639 were likely to progress developing N2 according to the TNM in BC patients.

conclusionsThese findings suggest that both SNPs on FSCN1 (rs3801004) and CD44 (rs353639) affected BC susceptibility. FSCN1 (rs3801004) genetic variants may have a significant effect on BC prognosis. However, CD44 (rs353639) affected lymph node invasions in BC patients.

Indexed as

Breast NeoplasmsCarrier ProteinsCase-Control StudiesEgyptEndothelial CellsFemaleGenetic Predisposition to DiseaseGenotypeHumansHyaluronan ReceptorsMicrofilament ProteinsPolymorphism, Single NucleotidePrognosisCarrier ProteinsCD44 protein, humanFSCN1 protein, humanHyaluronan ReceptorsMicrofilament Proteinsbreast cancerCD44Fascin-1(FSCN1)gene polymorphisms

Identifiers

PMID37898858
PMCPMC10770661
OpenAlexW4388014660

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.