Evidence map›Paper›PMID 37898777›Full record

ArticleJournal of nanobiotechnology2023

Superior TRAIL gene expression and cancer cell apoptosis mediated by highly branched-linear poly(β-amino ester)s.

Yitong Zhao, Tao Bo, Chenfei Wang, Dingjin Yao, Chaolan Pan, Weiyi Xu, Hao Zhou, Ming Li, Si Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yitong Zhao *School of Medicine, Anhui University of Science and Technology, 232000, Huainan, Anhui, China.
Tao Bo *NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 200032, Shanghai, China.
Chenfei Wang *Department of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, 201102, Shanghai, China. wangchenfei@fudan.edu.cn.
Dingjin YaoNHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 200032, Shanghai, China.
Chaolan PanDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, 201102, Shanghai, China.
Weiyi XuDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, 201102, Shanghai, China.
Hao ZhouState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, 300071, Tianjin, China.
Ming LiDepartment of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, 201102, Shanghai, China. mingli@fudan.edu.cn.
Si ZhangSchool of Medicine, Anhui University of Science and Technology, 232000, Huainan, Anhui, China. zhangsi@fudan.edu.cn.
Children's Hospital of Fudan University · CNFudan University · CNAnhui University of Science and Technology · CNState Key Laboratory of Medicinal Chemical Biology

Funding

Medical Engineering Cross Research Foundation of Shanghai Jiaotong University YG2022ZD010the Clinical Research Special Project of Shanghai Municipal Health Commission 20234Y0209the National Natural Science Foundation of China 82073422the National Natural Science Foundation of China (NSFC) 82270135the Outstanding Youth Fund of Natural Science Foundation of Anhui Province 2308085J27the Science and Technology Innovation Action Plan of Shanghai Science and Technology committee 21ZR1408900
6 · The paper itself

Abstract

Extensive efforts have been dedicated to enhancing the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer cells for the development of effective cancer treatments. However, highly safe and efficient delivery of TRAIL gene remains a significant challenge, especially using cationic polymers. Here, a series of highly branched-linear poly(β-amino ester)s (H-LPAEs) are developed through a unique oligomer branching strategy. H-LPAEs exhibit a more uniform distribution of linear segments and branching units, leading to excellent DNA condensation and favorable physicochemical properties of H-LPAE/DNA polyplexes. In SW1353 and BMSC cells, the optimized H-LPAEs, H-LPAE

Indexed as

EstersNeoplasmsAcrylatesApoptosisDNAGene ExpressionHeLa CellsHumansLigandsPolymersTransfectionAcrylatesDNAEstersLigandspoly(beta-amino ester)Polymerstrimethylolpropane triacrylateBranched-linear poly(β-amino ester)sCancer therapyCell apoptosisTRAIL gene

Identifiers

PMID37898777
PMCPMC10612241
OpenAlexW4388002120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.