ArticleEuropean journal of medical research2023
HOMA-IR is positively correlated with biological age and advanced aging in the US adult population.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Decoding the lipid etiology of atherogenic index of plasma and gout: establishing the causal role of triglycerides through NHANES, Mendelian randomization, and network pharmacology.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities.Archives of endocrinology and metabolism · 2026Article
- Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.Health science reports · 2026Article
- Association between cumulative TyG/AIP-derived indices and terminal survival time in older patients with circulatory system diseases.BMC geriatrics · 2026Article
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- Elevated cardiometabolic index is associated with an increased risk of cardiovascular and all-cause mortality in patients undergoing dialysis: a retrospective cohort study.BMC nephrology · 2026Article
- Relationship of HOMA-IR with chronic kidney disease in diabetic and non-diabetic Chinese populations: findings from the REACTION study.Frontiers in endocrinology · 2026Article
- Insulin resistance increases the risk of conversion to the subcortical small vessel type of dementia.Cerebral circulation - cognition and behavior · 2026Article
- The triglyceride-glucose index assesses mortality in patients with cerebral hemorrhage: a retrospective analysis based on a critical care medical database.BMC neurology · 2025Article
- Association between plasma extracellular vesicles LncRNAs and metabolic syndrome in polycystic ovary syndrome.Journal of ovarian research · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- A High-Fat Diet Induces Oxidative Stress in OPA1Antioxidants (Basel, Switzerland) · 2025Article
- Gene-Embedded Multi-Modal Networks for Population-Scale Multi-Omics Discovery.bioRxiv : the preprint server for biology · 2025Article
- Association between eGDR and accelerated aging: the mediating role of ePWV.Diabetology & metabolic syndrome · 2025Article
- Article
- Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration.Cardiovascular diabetology · 2025Article
- Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey.Cardiovascular diabetology · 2025Article
- Association of dietary inflammatory index and vigorous physical activity on phenotypic age acceleration: a cross-sectional study with machine learning.Frontiers in nutrition · 2025Article
- Retrospective Analysis of the Efficacy of Integrated Lifestyle Modifications in Managing Prediabetes in the Indian Population.Journal of diabetes research · 2025Article
- Association of the Triglyceride-Glucose Index With Resistant Hypertension and a Nomogram Model Construction.Journal of the American Heart Association · 2024Article
Corrections and comments
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6 authors.
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Abstract
backgroundInsulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross-sectional study is to explore the relationship between HOMA-IR and BA/advanced aging in the US population.
methodsThis study is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data. The survey comprised 12,266 people from the NHANES, and their full HOMA-IR data as well as BA data were extracted. Four multiple linear regressions were performed to analyze the association between HOMA-IR and BA, and four multiple logistic regression models were performed to analyze the association between HOMA-IR and advanced aging. In addition, trend tests and stratified analysis were performed and smoothed fitted curves were plotted to test the robustness of the results.
resultsHOMA-IR was positively correlated with BA [β: 0.51 (0.39, 0.63)], and it was the same to advanced aging [OR: 1.05 (1.02, 1.07)], and both showed a monotonically increasing trend. The trend tests showed that the results were stable (all P for trend < 0.0001). The smoothed fitted curves showed that there were non-linear relationships between HOMA-IR and BA/advanced aging. And the stratified analysis indicated that the relationship between HOMA-IR and BA/advanced aging remained robust in all subgroups.
conclusionThe study suggested that HOMA-IR is positively correlated with BA and advanced aging in the US adult population, with a monotonic upward trend. This is a new finding to reveal the relationship between HOMA-IR and age from new standpoint of BA rather than chronological age (CA). And it may contribute to a better understanding of human health aging and may aid future research in this field.
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