Evidence map›Paper›PMID 37898719›Full record

ArticleScientific reports2023

Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.

Hiroki Kamada, Kousuke Emura, Rikuto Yamamoto, Koichi Kawahara, Sadahito Uto, Toshiaki Minami, Seiji Ito, Ken-Ichi Matsumoto, Emiko Okuda-Ashitaka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hiroki KamadaDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan.
Kousuke EmuraDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan.
Rikuto YamamotoDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan.
Koichi KawaharaDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan.
Sadahito UtoDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan.
Toshiaki MinamiDepartment of Anesthesiology, Osaka Medical and Pharmaceutical University, Takatsuki, 569-8686, Japan.
Seiji ItoDepartment of Anesthesiology, Osaka Medical and Pharmaceutical University, Takatsuki, 569-8686, Japan.
Ken-Ichi MatsumotoDepartment of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Head Office for Research and Academic Information, Shimane University, Izumo, 693-8501, Japan.
Emiko Okuda-AshitakaDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, 535-8585, Japan. emiko.ashitaka@oit.ac.jp.
Osaka Institute of Technology · JPOsaka University of Pharmaceutical Sciences · JPShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficiency of an extracellular matrix glycoprotein tenascin-X (TNX) leads to a human heritable disorder Ehlers-Danlos syndrome, and TNX-deficient patients complain of chronic joint pain, myalgia, paresthesia, and axonal polyneuropathy. We previously reported that TNX-deficient (Tnxb

Indexed as

Ehlers-Danlos SyndromeHyperalgesiaAnimalsExtracellular MatrixFlagellinHumansLidocaineMiceNerve Fibers, UnmyelinatedTenascinToll-Like Receptor 5FlagellinLidocaineQX-314Tenascintenascin XTlr5 protein, mouseToll-Like Receptor 5

Identifiers

PMID37898719
PMCPMC10613304
OpenAlexW4388033435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.