Evidence map›Paper›PMID 37898691›Full record

ArticleScientific reports2023

Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.

Kathleen Ferar, Taryn O Hall, Dana C Crawford, Robb Rowley, Benjamin A Satterfield, Rongling Li, Loren Gragert, Elizabeth W Karlson, Mariza de Andrade, Iftikhar J Kullo and 16 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 17 institutions in 1 country.

Kathleen FerarDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA. kmuenzen@uw.edu.
Taryn O HallOptum Genomics, UnitedHealth Group, Minnetonka, MN, USA.
Dana C CrawfordDepartment of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Robb RowleyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Benjamin A SatterfieldDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Rongling LiNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Loren GragertDivision of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Elizabeth W KarlsonDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Mariza de AndradeDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Iftikhar J KulloDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Catherine A McCartyUniversity of Minnesota Medical School, Duluth, MN, USA.
Abel KhoDivisions of General Internal Medicine and Preventive Medicine, Northwestern University, Chicago, IL, USA.
M Geoffrey HayesDivision of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Marylyn D RitchieDepartment of Biochemistry and Molecular Biology, Center for Systems Genomics, Pennsylvania State University, University Park, PA, USA.
Paul K CraneDivision of General Internal Medicine, University of Washington, Seattle, WA, USA.
Daniel B MirelScilligence Corp., Cambridge, MA, USA.
Christopher CarlsonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
John J ConnollyCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hakon HakonarsonDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Andrew T CrenshawThe Broad Institute of Harvard-MIT, Cambridge, MA, USA.
David CarrellKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Yuan LuoNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ozan DikilitasDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Gail P JarvikDepartment of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA.
David R CrosslinDivision of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA. crosslin@tulane.edu.
Mayo Clinic in Arizona · USNorthwestern University · USChildren's Hospital of Philadelphia · USNational Institutes of Health · USTulane University · USUniversity of Washington Medical Center · USBrigham and Women's Hospital · USBroad Institute · USCase Western Reserve University · USFred Hutch Cancer Center · USKaiser Permanente Washington Health Research Institute · USMarshfield Clinic · USMayo Clinic · USPennsylvania State University · USUnitedHealth Group (United States) · USUniversity of Washington · USVanderbilt University · US

Funding

A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
eMERGE Coordinating Center - Administrative SupplementU01HG006385 · NHGRI · VANDERBILT UNIVERSITY · PI HARRIS, PAUL A. · 2011 to 2014
$5.4M
The Future of Genomics Medicine in Patient Care: Contributions from CHOPU01HG008684 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2015 to 2019
$5.0M
Biorepository for Genomic Medicine in diverse CommunitiesU01HG006380 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOTTINGER, ERWIN P. · 2011 to 2015
$4.5M
Geisinger eGenonic Medicine (GeM) ProgramU01HG006382 · NHGRI · GEISINGER CLINIC · PI CAREY, DAVID J., WILLIAMS, MARC S. · 2011 to 2014
$4.3M
Better Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2M
A Personalized Genomic Medicine Pilot Program Using the NJgene eMERGE ExperienceU01HG006388 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHISHOLM, REX L, SMITH, MAUREEN E · 2011 to 2014
$4.1M
IRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1M
Genetic Discovery and Application in a Clinical Setting Continuing a PartnershipU01HG006375 · NHGRI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI JARVIK, GAIL PAIRITZ, LARSON, ERIC B · 2011 to 2014
$4.1M
NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01HG004424NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01HG006389NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01HG008685NHGRI NIH HHS U01HG8684
6 · The paper itself

Abstract

Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some patients with colons that are colonized with C. diff. do not develop any infection while others develop severe or recurrent infections. To identify common genetic variants associated with CDI, we performed a genome-wide association analysis in 19,861 participants (1349 cases; 18,512 controls) from the Electronic Medical Records and Genomics (eMERGE) Network. Using logistic regression, we found strong evidence for genetic variation in the DRB locus of the MHC (HLA) II region that predisposes individuals to CDI (P > 1.0 × 10

Indexed as

Clostridium InfectionsGenome-Wide Association StudyDiarrheaGenetic VariationHistocompatibility AntigensHistocompatibility Antigens Class IIHLA AntigensHumansHistocompatibility AntigensHistocompatibility Antigens Class IIHLA Antigens

Identifiers

PMID37898691
PMCPMC10613277
OpenAlexW4388005625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.