Evidence map›Paper›PMID 37898655›Full record

ArticleNature communications2023

Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state.

In-Jee You, Yeeun Bae, Alec R Beck, Sora Shin

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

In-Jee You *Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Yeeun Bae *Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Alec R BeckFralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Sora ShinFralin Biomedical Research Institute at VTC, Roanoke, VA, USA. srshin@vtc.vt.edu.ORCID 0000-0002-1047-3384
Biomedical Research Institute · USRoanoke College · US

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
A leptin-responsive lateral hypothalamus to ventrolateral periaqueductal gray circuit for palatable food overconsumptionR01DK132566 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Sora Shin · 2022 to 2026
$2.1M
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NIDDK NIH HHS R01 DK132566
6 · The paper itself

Abstract

Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter feeding-related hypothalamic circuit functions. Here, we found that proenkephalin (Penk)-expressing lateral hypothalamic (LH

Indexed as

Hypothalamic Area, LateralNeuronsAnimalsEnkephalinsHyperphagiaMiceProtein PrecursorsEnkephalinsproenkephalinProtein Precursors

Identifiers

PMID37898655
PMCPMC10613253
OpenAlexW4388034196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.