Evidence map›Paper›PMID 37898651›Full record

ArticleScientific reports2023

Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model.

Nabarun Chakraborty, Gregory P Holmes-Hampton, Aarti Gautam, Raina Kumar, Bernadette Hritzo, Betre Legesse, George Dimitrov, Sanchita P Ghosh, Rasha Hammamieh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nabarun ChakrabortyMedical Readiness Systems Biology, CMPN, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
Gregory P Holmes-HamptonArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, 20889, USA.
Aarti GautamMedical Readiness Systems Biology, CMPN, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
Raina KumarThe Geneva Foundation, US Army Center for Environmental Health Research, Fort Detrick, MD, 21702-5010, USA.
Bernadette HritzoArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, 20889, USA.
Betre LegesseArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, 20889, USA.
George DimitrovMedical Readiness Systems Biology, CMPN, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
Sanchita P GhoshArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, 20889, USA. Sanchita.ghosh@usuhs.edu.
Rasha HammamiehMedical Readiness Systems Biology, CMPN, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
Uniformed Services University of the Health Sciences · USWalter Reed Army Institute of Research · USThe Geneva Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis of lethal radiation is imperative since its intervention time windows are considerably short. Hence, ideal diagnostic candidates of radiation should be easily accessible, enable to inform about the stress history and objectively triage subjects in a time-efficient manner. Therefore, the small molecules such as metabolites and microRNAs (miRNAs) from plasma are legitimate biomarker candidate for lethal radiation. Our objectives were to comprehend the radiation-driven molecular pathogenesis and thereby determine biomarkers of translational potential. We investigated an established minipig model of LD70/45 total body irradiation (TBI). In this pilot study, plasma was collected pre-TBI and at multiple time points post-TBI. The majority of differentially expressed miRNAs and metabolites were perturbed immediately after TBI that potentially underlined the severity of its acute impact. The integrative network analysis of miRNA and metabolites showed a cohesive response; the early and consistent perturbations of networks were linked to cancer and the shift in musculoskeletal atrophy synchronized with the comorbidity-networks associated with inflammation and bioenergy synthesis. Subsequent comparative pipeline delivered 92 miRNAs, which demonstrated sequential homology between human and minipig, and potentially similar responses to lethal radiation across these two species. This panel promised to retrospectively inform the time since the radiation occurred; thereby could facilitate knowledge-driven interventions.

Indexed as

Circulating MicroRNAMicroRNAsAnimalsBiomarkersHumansPilot ProjectsRetrospective StudiesSwineSwine, MiniatureBiomarkersCirculating MicroRNAMicroRNAs

Identifiers

PMID37898651
PMCPMC10613244
OpenAlexW4388001484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.