Evidence map›Paper›PMID 37898567›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2025

Agreement of cerebrospinal fluid biomarkers and amyloid-PET in a multicenter study.

Núria Guillén, José Contador, Mariateresa Buongiorno, Ignacio Álvarez, Natalia Culell, Daniel Alcolea, Alberto Lleó, Juan Fortea, Gerard Piñol-Ripoll, Anna Carnes-Vendrell and 7 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Sequential scans ofJapanese journal of radiology · 2026
    Article
  2. Article
  3. Sex differences in vulnerability to tau pathology: Impact on cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Núria GuillénAlzheimer's Disease and Other Cognitive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1341-9834
José ContadorAlzheimer's Disease and Other Cognitive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain.
Mariateresa BuongiornoMemory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
Ignacio ÁlvarezMemory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
Natalia CulellMemory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
Daniel AlcoleaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.
Alberto LleóSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.
Juan ForteaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain.
Gerard Piñol-RipollClinical Neuroscience Research, Unitat Trastorns Cognitius, IRBLleida, Santa Maria University Hospital, Lleida, Spain.
Anna Carnes-VendrellClinical Neuroscience Research, Unitat Trastorns Cognitius, IRBLleida, Santa Maria University Hospital, Lleida, Spain.
María Lourdes IspiertoNeurodegenerative Diseases Unit, Neurology Service and Neurosciences Department, University Hospital Germans Trias i Pujol (HUGTP), Badalona, Spain.
Dolores VilasNeurodegenerative Diseases Unit, Neurology Service and Neurosciences Department, University Hospital Germans Trias i Pujol (HUGTP), Badalona, Spain.
Albert Puig-PijoanCognitive Decline and Movement Disorders Unit, Neurology Department, Hospital del Mar, Barcelona, Spain.
Aida Fernández-LebreroCognitive Decline and Movement Disorders Unit, Neurology Department, Hospital del Mar, Barcelona, Spain.
Mircea BalasaAlzheimer's Disease and Other Cognitive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain.
Raquel Sánchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain.
Albert LladóAlzheimer's Disease and Other Cognitive Disorders Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain. allado@clinic.cat.
Hospital Clínic de Barcelona · ESUniversitat Autònoma de Barcelona · ESUniversity Hospital Mútua de Terrassa · ESHospital Del Mar · ESHospital Universitari de Santa Maria · ESHospital Universitari Germans Trias i Pujol · ESNeurosciences Institute · US

Funding

The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-RevisionRF1AG056850 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSCIGLIO, JORGE A, CUELLO, A CLAUDIO · 2018 to 2020
$5.9M
Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Biological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414k
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Alzheimer DiseaseCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Program 1Departament de Salut, Generalitat de Catalunya AGAURDepartament de Salut, Generalitat de Catalunya PERIS 2016-2020 SLT008/18/00061Departament de Salut, Generalitat de Catalunya PERIS 2019 SLT008/18/00050Departament de Salut, Generalitat de Catalunya PERIS SLT002/16/408Departament de Salut, Generalitat de Catalunya SLT006/17/119Departament de Salut, Generalitat de Catalunya SLT006/17/125Diputació de Lleida PIRS2021Foundation for the National Institutes of Health 1R01AG056850-01A1Foundation for the National Institutes of Health R01AG061566Foundation for the National Institutes of Health R21AG056974Fundació Docència i Recerca Mútua de Terrassa 2022Fundació la Marató de TV3 20141210Fundació la Marató de TV3 20142610Instituto de Salud Carlos III AC19/00103Instituto de Salud Carlos III FI20/00076Instituto de Salud Carlos III INT19/00016Instituto de Salud Carlos III PI14/01126Instituto de Salud Carlos III PI17/01019Instituto de Salud Carlos III PI17/01896Instituto de Salud Carlos III PI18/00435Instituto de Salud Carlos III PI19/00449Instituto de Salud Carlos III PI20/01473NIA NIH HHS R21 AG056974NIA NIH HHS RF1 AG056850NIA NIH HHS RF1 AG061566
6 · The paper itself

Abstract

Core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers have shown incomplete agreement with amyloid-positron emission tomography (PET). Our goal was to analyze the agreement between AD CSF biomarkers and amyloid-PET in a multicenter study. Retrospective multicenter study (5 centers). Participants who underwent both CSF biomarkers and amyloid-PET scan within 18 months were included. Clinical diagnoses were made according to latest diagnostic criteria by the attending clinicians. CSF Amyloid Beta

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionPeptide FragmentsPositron-Emission Tomographytau ProteinsAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide Fragmentstau ProteinsAlzheimer’s diseaseAmyloid-PETBiomarkersCSF

Identifiers

PMID37898567
PMCPMC11799063
OpenAlexW4388007359

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.