ArticleNeuropsychologia2023
Resting state network connectivity is associated with cognitive flexibility performance in youth in the Adolescent Brain Cognitive Development Study.
Article in Neuropsychologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real-Time fMRI Neurofeedback.Depression and anxiety · 2025Trial
- Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts.Biological psychiatry · 2026Review
- Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non-psychotic adolescent depression during verbal fluency.Frontiers in psychiatry · 2026Article
- Common and unique network basis for externally and internally driven flexibility in cognition: From a developmental perspective.Developmental cognitive neuroscience · 2025Article
- Time-varying brain state dynamics in trait impulsivity and anxiety: An HSMM analysis of resting-state fMRI.Social cognitive and affective neuroscience · 2025Article
- Neurophysiology of Resilience in Juvenile Fibromyalgia.medRxiv : the preprint server for health sciences · 2024Article
- Two Sides of Theory of Mind: Mental State Attribution to Moving Shapes in Paranoid Schizophrenia Is Independent of the Severity of Positive Symptoms.Brain sciences · 2024Article
- Neurodevelopment of the functional connectivity of the salience network in facial emotion recognition from adolescence to adulthood.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
3 authors.
Funding
Abstract
Cognitive flexibility is an executive functioning skill that develops in childhood, and when impaired, has transdiagnostic implications for psychiatric disorders. To identify how intrinsic neural architecture at rest is linked to cognitive flexibility performance, we used the data-driven method of independent component analysis (ICA) to investigate resting state networks (RSNs) and their whole-brain connectivity associated with levels of cognitive flexibility performance in children. We hypothesized differences by cognitive flexibility performance in RSN connectivity strength in cortico-striatal circuitry, which would manifest via the executive control network, right and left frontoparietal networks (FPN), salience network, default mode network (DMN), and basal ganglia network. We selected participants from the Adolescent Brain Cognitive Development (ABCD) Study who scored at the 25th, ("CF-Low"), 50th ("CF-Average"), or 75th percentiles ("CF-High") on a cognitive flexibility task, were early to middle puberty, and did not exhibit significant psychopathology (n = 967, 47.9% female; ages 9-10). We conducted whole-brain ICA, identifying 14 well-characterized RSNs. Groups differed in connectivity strength in the right FPN, anterior DMN, and posterior DMN. Planned comparisons indicated CF-High had stronger connectivity between right FPN and supplementary motor/anterior cingulate than CF-Low. CF-High had more anti-correlated connectivity between anterior DMN and precuneus than CF-Average. CF-Low had stronger connectivity between posterior DMN and supplementary motor/anterior cingulate than CF-Average. Post-hoc correlations with reaction time by trial type demonstrated significant associations with connectivity. In sum, our results suggest childhood cognitive flexibility performance is associated with DMN and FPN connectivity strength at rest, and that there may be optimal levels of connectivity associated with task performance that vary by network.
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