ArticleEBioMedicine2023
Complementary structural and functional abnormalities to localise epileptogenic tissue.
Article in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Open diffusion magnetic resonance imaging and connectivity data for epilepsy and surgery: The IDEAS II release.Epilepsia · 2026Article
- Multimodal artificial intelligence in epilepsy: antiseizure medication response, epileptogenic zone localization, and surgical outcome prediction.Frontiers in neurology · 2026Review
- Article
- Seizure freedom after surgical resection of diffusion-weighted magnetic resonance imaging abnormalities.Epilepsia · 2025Article
- Surgical targeting of lateralizedEpilepsia · 2025Article
- From Bedside to Desktop: A Data Protocol for Normative Intracranial EEG and Abnormality Mapping.Bio-protocol · 2025Article
- Automated generation of epilepsy surgery resection masks: The RAMPS pipeline.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Vagus nerve stimulation for epilepsy: A narrative review of factors predictive of response.Epilepsia · 2024Review
- Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo.Nature communications · 2024Article
- Normative brain mapping using scalp EEG and potential clinical application.Scientific reports · 2023Article
- Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue.Epilepsia · 2023Article
- Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome.ArXiv · 2023Article
- Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome.Brain communications · 2023Article
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Abstract
backgroundWhen investigating suitability for epilepsy surgery, people with drug-refractory focal epilepsy may have intracranial EEG (iEEG) electrodes implanted to localise seizure onset. Diffusion-weighted magnetic resonance imaging (dMRI) may be acquired to identify key white matter tracts for surgical avoidance. Here, we investigate whether structural connectivity abnormalities, inferred from dMRI, may be used in conjunction with functional iEEG abnormalities to aid localisation of the epileptogenic zone (EZ), improving surgical outcomes in epilepsy.
methodsWe retrospectively investigated data from 43 patients (42% female) with epilepsy who had surgery following iEEG. Twenty-five patients (58%) were free from disabling seizures (ILAE 1 or 2) at one year. Interictal iEEG functional, and dMRI structural connectivity abnormalities were quantified by comparison to a normative map and healthy controls. We explored whether the resection of maximal abnormalities related to improved surgical outcomes, in both modalities individually and concurrently. Additionally, we suggest how connectivity abnormalities may inform the placement of iEEG electrodes pre-surgically using a patient case study.
findingsSeizure freedom was 15 times more likely in patients with resection of maximal connectivity and iEEG abnormalities (p = 0.008). Both modalities separately distinguished patient surgical outcome groups and when used simultaneously, a decision tree correctly separated 36 of 43 (84%) patients.
interpretationOur results suggest that both connectivity and iEEG abnormalities may localise epileptogenic tissue, and that these two modalities may provide complementary information in pre-surgical evaluations.
fundingThis research was funded by UKRI, CDT in Cloud Computing for Big Data, NIH, MRC, Wellcome Trust and Epilepsy Research UK.
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