Evidence map›Paper›PMID 37898036›Full record

ArticleDiagnostic microbiology and infectious disease2024

Evaluation of the analytical performance of the 15-minute point-of-care DASH™ SARS-CoV-2 RT-qPCR test.

Matthew A Butzler, Jennifer L Reed, Kirsten M Knapton, Tania Afzal, Abhishek K Agarwal, Jakob Schaeffer, Neeraj Saraiya, Lisa Oti, Ezekiel R White, Emilie Giacobbe and 3 more

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Development of a Rapid Automated Point-of-Care Test formedRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matthew A ButzlerCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Jennifer L ReedCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Kirsten M KnaptonCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Tania AfzalCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Abhishek K AgarwalCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Jakob SchaefferCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Neeraj SaraiyaCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Lisa OtiCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Ezekiel R WhiteCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Emilie GiacobbeCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States.
Lacy M SimonsCenter for Pathogen Genomics and Microbial Evolution (CPGME), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States.
Egon A OzerCenter for Pathogen Genomics and Microbial Evolution (CPGME), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States.
Sally M McFallCenter for Innovation in Global Health Technologies (CIGHT), Robert J. Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 United States. Electronic address: s-mcfall@northwestern.edu.

Funding

The Center for Innovation in Point-of-Care Technologies for HIV/AIDS atNorthwestern University (C-THAN) Supplemental RequestU54EB027049 · NIBIB · NORTHWESTERN UNIVERSITY · PI Chad J Achenbach, SALLY Maureen MCFALL · 2018 to 2026
$24.0M
THE PURPOSE OF THIS MODIFICATION IS TO UPDATE THE DELIVERABLE DUE DATES FOR RADX TECH PROJECT 220075N92021C00013 · NHLBI · PI NARAJOWSKI, WALLY · 2021 to 2021
$21.3M
NHLBI NIH HHS 75N92021C00013NIBIB NIH HHS U54 EB027049
6 · The paper itself

Abstract

Accurate and timely diagnosis for COVID-19 diagnosis allows highly effective antiviral medications to be prescribed. The DASH™ Rapid PCR System is a sample-to-answer point-of-care platform combining state-of-the-art PCR kinetics with sequence specific hybridization. The platform's first assay, the DASH™ SARS-CoV-2/S test for anterior nares direct swab specimens, received FDA Emergency Use Authorization in March 2022 for point-of-care use. Here we report the analytical characteristics of the assay including limit of detection, dynamic range, and robustness of SARS-CoV-2 variant detection. The limit of detection was determined by testing swabs contrived with one hundred copies of wild type or Omicron BA.5 virus and detecting 20/20 and 19/20, respectively. The dynamic range was assessed with contrived swabs containing 10

Indexed as

COVID-19Point-of-Care SystemsCOVID-19 TestingHumansSARS-CoV-2Sensitivity and SpecificityCOVID-19DiagnosisPoint-of-CareQuantitative PCR

Identifiers

PMID37898036
PMCPMC10842742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.