Evidence map›Paper›PMID 37897625›Full record

ArticleCerebellum (London, England)2024

A Novel Paired Somatosensory-Cerebellar Stimulation Induces Plasticity on Cerebellar-Brain Connectivity.

Francesca Ginatempo, Nicoletta Manzo, Danny A Spampinato, Nicola Loi, Francesca Burgio, John C Rothwell, Franca Deriu

Open access · hybridAbstract read
In one paragraph

Article in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Francesca GinatempoDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy.
Nicoletta ManzoIRCCS San Camillo, Via Alberoni, 70, Venice, Italy.
Danny A SpampinatoDepartment of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Nicola LoiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy.
Francesca BurgioIRCCS San Camillo, Via Alberoni, 70, Venice, Italy.
John C RothwellSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.
Franca DeriuDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy. deriuf@uniss.it.ORCID https://orcid.org/0000-0001-8235-6091
University of Sassari · ITIRCCS San Camillo Hospital · ITFondazione Santa Lucia · ITSobell House · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum receives and integrates a large amount of sensory information that is important for motor coordination and learning. The aim of the present work was to investigate whether peripheral nerve and cerebellum paired associative stimulation (cPAS) could induce plasticity in both the cerebellum and the cortex. In a cross-over design, we delivered right median nerve electrical stimulation 25 or 10 ms before applying transcranial magnetic stimulation over the cerebellum. We assessed changes in motor evoked potentials (MEP), somatosensory evoked potentials (SEP), short-afferent inhibition (SAI), and cerebellum-brain inhibition (CBI) immediately, and 30 min after cPAS. Our results showed a significant reduction in CBI 30 minutes after cPAS, with no discernible changes in MEP, SEP, and SAI. Notably, cPAS10 did not produce any modulatory effects on these parameters. In summary, cPAS25 demonstrated the capacity to induce plasticity effects in the cerebellar cortex, leading to a reduction in CBI. This novel intervention may be used to modulate plasticity mechanisms and motor learning in healthy individuals and patients with neurological conditions.

Indexed as

CerebellumEvoked Potentials, MotorEvoked Potentials, SomatosensoryMedian NerveNeuronal PlasticityTranscranial Magnetic StimulationAdultCross-Over StudiesElectric StimulationElectromyographyFemaleHumansMaleNeural InhibitionNeural PathwaysYoung AdultCerebellar stimulationLong-term depressionPaired associative stimulationPeripheral stimulationTranscranial magnetic stimulation

Identifiers

PMID37897625
PMCPMC11102379
OpenAlexW4388007399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.