Evidence map›Paper›PMID 37897341›Full record

ArticleNucleic acids research2024

The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.

Simon D Harding, Jane F Armstrong, Elena Faccenda, Christopher Southan, Stephen P H Alexander, Anthony P Davenport, Michael Spedding, Jamie A Davies

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
42.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. The evolving landscape of drug targets.Nature reviews. Drug discovery · 2026
    Review
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  11. Inhibition of (interstitial) P2YPflugers Archiv : European journal of physiology · 2026
    Article
  12. Attention-Guided Multi-View Contrastive Learning for Predicting Sparse Drug-Gene Associations.Interdisciplinary sciences, computational life sciences · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Inhibition of (interstitial) P2YResearch square · 2026
    Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Simon D HardingCentre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.ORCID 0000-0002-9262-8318
Jane F ArmstrongCentre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Elena FaccendaCentre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Christopher SouthanCentre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Stephen P H AlexanderSchool of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.
Michael SpeddingSpedding Research Solutions SAS, Le Vésinet 78110, France.
Jamie A DaviesCentre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
University of Edinburgh · GBUniversity of Cambridge · GBUniversity of Nottingham · GB

Funding

Wellcome TrustWellcome Trust 108420/Z/15/Z
6 · The paper itself

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental ligands. It includes over 3039 protein targets and 12 163 ligand molecules, including approved drugs, small molecules, peptides and antibodies. Here, we report recent developments to the resource and describe expansion in content over the six database releases made during the last two years. The database update section of this paper focuses on two areas relating to important global health challenges. The first, SARS-CoV-2 COVID-19, remains a major concern and we describe our efforts to expand the database to include a new family of coronavirus proteins. The second area is antimicrobial resistance, for which we have extended our coverage of antibacterials in partnership with AntibioticDB, a collaboration that has continued through support from GARDP. We discuss other areas of curation and also focus on our external links to resources such as PubChem that bring important synergies to the resources.

Indexed as

Databases, PharmaceuticalDrug DiscoveryProteinsLigandsLigandsProteins

Identifiers

PMID37897341
PMCPMC10767925
OpenAlexW4388007339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.