SynthesisMultiple sclerosis (Houndmills, Basingstoke, England)2023
Mobile health interventions in multiple sclerosis: A systematic review.
Synthesis in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The Measurement Properties and Applications of WHODAS 2.0 in Multiple Sclerosis: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- E-based physical exercise in patients with multiple sclerosis and comorbidity (COMPACT): feasibility study and protocol for a randomized controlled trial.Frontiers in immunology · 2026Trial
- Neurostatus-SMARTCARE clinical trial: Enabling health care professionals to assess EDSS for decentralized trials in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Trial
- Effectiveness of a digital lifestyle management intervention (levidex) to improve quality of life in people with multiple sclerosis: results of a randomized controlled trial.BMC neurology · 2024Trial
- Artificial Intelligence Applications to Support Physical Activity, Mobility, and Fatigue Management in People with Multiple Sclerosis: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Digital patient experience tools in multiple sclerosis: a landscape analysis of the global Patient-Reported Outcomes in Multiple Sclerosis (PROMS) initiative.EClinicalMedicine · 2026Article
- Healthcare effects and evidence robustness of reimbursable digital health applications in Germany: a systematic review.NPJ digital medicine · 2025Article
- Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature.Neurology and therapy · 2025Review
- Gamification-Based Interventions in Chronic Disease Care: A Systematic Review of Randomised Controlled Trials.Risk management and healthcare policy · 2025Review
- Factors influencing health behavior changes in people with early multiple sclerosis: process evaluation of the multicenter randomized controlled POWER@MS1 trial.Frontiers in neurology · 2025Article
- Smoking and multiple sclerosis: development and feasibility study of a MS-specific smoking cessation intervention.Therapeutic advances in neurological disorders · 2025Article
- Application of telemedicine in fatigue management for patients with multiple sclerosis: A scoping review.PloS one · 2025Article
- Connecting the dots: the role of fatigue in female infertility.Reproductive biology and endocrinology : RB&E · 2024Review
- Review
- Effectiveness of a digital health application (Multiple sclerosis journal - experimental, translational and clinicalArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersons with multiple sclerosis (pwMS) might be particularly well suited to benefit from digital health applications because they are, on average, younger and less severely disabled than patients with many other chronic diseases. Many digital health applications for pwMS have been developed.
objectivesAnalysis of the evidence of digital health applications to improve health outcomes from a patient perspective.
methodsA systematic review was performed on all randomized controlled trials (RCTs) that have studied mobile health interventions for pwMS, that is, which can be applied with a smartphone, tablet, or laptop to improve patient-reported outcomes.
resultsOf the 1127 articles identified in the literature search, 13 RCTs fit the inclusion criteria. Two trials studied messaging systems, two depression interventions, one addressed MS fatigue, five cognition, and three mobility issues, of which two focused on spasticity management. One trial aimed to enhance physical activity. Most were pilot studies that cannot yield definitive conclusions regarding efficacy. One depression intervention and one fatigue intervention showed significant results across several outcomes.
conclusionSeveral mobile self-guided digital health applications for pwMS have been tested in RCTs, and two interventions targeting depression and fatigue have demonstrated significant effects. Challenges remain regarding implementation into routine care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.