Evidence map›Paper›PMID 37896986›Full record

ArticleVaccines2023

Immune Profile Determines Response to Vaccination against COVID-19 in Kidney Transplant Recipients.

Stamatia Stai, Asimina Fylaktou, Efstratios Kasimatis, Aliki Xochelli, Georgios Lioulios, Vasiliki Nikolaidou, Anastasia Papadopoulou, Grigorios Myserlis, Artemis Maria Iosifidou, Myrto Aikaterini Iosifidou and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Stamatia StaiSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Asimina FylaktouDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Efstratios KasimatisSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Aliki XochelliDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Georgios LiouliosSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Vasiliki NikolaidouDepartment of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Anastasia PapadopoulouHematology Department, Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, "George Papanikolaou" Hospital, 57010 Thessaloniki, Greece.ORCID 0000-0001-5385-8738
Grigorios MyserlisSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Artemis Maria IosifidouSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Myrto Aikaterini IosifidouSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Aikaterini PapagianniSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Evangelia YannakiHematology Department, Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, "George Papanikolaou" Hospital, 57010 Thessaloniki, Greece.
Georgios TsoulfasSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Maria StangouSchool of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.ORCID 0000-0003-2496-9863
Aristotle University of Thessaloniki · GRHippocration General Hospital · GRG. Papanikolaou General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimImmune status profile can predict response to vaccination, while lymphocyte phenotypic alterations represent its effectiveness. We prospectively evaluated these parameters in kidney transplant recipients (KTRs) regarding Tozinameran (BNT162b2) vaccination.

methodIn this prospective monocenter observational study, 39 adult KTRs, on stable immunosuppression, naïve to COVID-19, with no protective humoral response after two Tozinameran doses, received the third vaccination dose, and, based on their immunity activation, they were classified as responders or non-responders. Humoral and cellular immunities were assessed at predefined time points (T

resultsResponders, compared to non-responders, had a higher total and transitional B-lymphocyte count at baseline (96.5 (93) vs. 51 (52)cells/μL,

conclusionsResponders and non-responders to the third BNT162b2 dose demonstrated distinct initial immune cell profiles and changes in cellular subpopulation composition following vaccination.

Indexed as

cellular responseCOVID-19 vaccinationELISpotkidney transplantationlymphocytesprotective humoral response

Identifiers

PMID37896986
PMCPMC10611345
OpenAlexW4387528793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.