Evidence map›Paper›PMID 37896966›Full record

ArticleVaccines2023

Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8

Justa Friebus-Kardash, Theresa Charlotte Christ, Nikolaus Dietlein, Abdelrahman Elwy, Hossam Abdelrahman, Lisa Holnsteiner, Zhongwen Hu, Hans-Reimer Rodewald, Karl Sebastian Lang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Justa Friebus-KardashInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-6747-1240
Theresa Charlotte ChristInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Nikolaus DietleinDivision of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.
Abdelrahman ElwyInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0009-0006-1441-5460
Hossam AbdelrahmanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Lisa HolnsteinerInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Zhongwen HuInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Hans-Reimer RodewaldDivision of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.
Karl Sebastian LangInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
University of Duisburg-Essen · DEGerman Cancer Research Center · DE

Funding

Clinician Scientist Program of the University Medicine Essen Clinician Scientist Academy (UMEA) none
6 · The paper itself

Abstract

Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the current study, we investigated the role of Usp22 deficiency in acute viral infection with lymphocytic choriomeningitis virus (LCMV). We found that the lack of Usp22 on bone marrow-derived cells (Usp22

Indexed as

activation of CD8+ T cellsLCMVliver failurePD-L1 downregulationubiquitin-specific peptidase 22 (Usp22)

Identifiers

PMID37896966
PMCPMC10610587
OpenAlexW4387369785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.