Evidence map›Paper›PMID 37896877›Full record

ArticleViruses2023

Use of Remdesivir in Patients Hospitalized for COVID-19 Pneumonia: Effect on the Hypoxic and Inflammatory State.

Alessandro Libra, Nicola Ciancio, Gianluca Sambataro, Enrico Sciacca, Giuseppe Muscato, Andrea Marino, Carlo Vancheri, Lucia Spicuzza

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alessandro LibraRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Nicola CiancioRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Gianluca SambataroRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-9933-1202
Enrico SciaccaRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Giuseppe MuscatoRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8587-9151
Andrea MarinoDepartment of Biomedical and Biotechnological Sciences, Unit of Infectious Diseases, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5650-6911
Carlo VancheriRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Lucia SpicuzzaRegional Referral Centre for Rare Lung Disease, University Hospital "Policlinico-San Marco", Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remdesivir is one of the most attractive options for patients with hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19). The aim of our study was to evaluate the effect of remdesivir on the hypoxic and inflammatory state in patients with moderate to severe COVID-19. We retrospectively enrolled 112 patients admitted for COVID-19 pneumonia, requiring low-flow oxygen, 57 treated with remdesivir plus standard of care (SoC) and 55 treated only with SoC that were similar for demographic and clinical data. We evaluated changes in hypoxemia and inflammatory markers at admission (Day 0) and after 5 days of treatment (Day 5) and the clinical course of the disease. From Day 0 to Day 5, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (P/F) increased from 222 ± 62 to 274 ± 97 (

Indexed as

COVID-19Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19 Drug TreatmentHumansHypoxiaOxygenRetrospective StudiesSARS-CoV-2Treatment OutcomeAdenosine MonophosphateAlanineAntiviral AgentsOxygenremdesivirantiviral therapyIL6P/F ratioremdesivirrespiratory failureSARS-CoV-2

Identifiers

PMID37896877
PMCPMC10612076
OpenAlexW4387702968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.