SynthesisViruses2023
Clinical Severity of SARS-CoV-2 Variants during COVID-19 Vaccination: A Systematic Review and Meta-Analysis.
Synthesis in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Severity of COVID-19 Omicron Variants: A Global Systematic Review.Infectious diseases and therapy · 2026Pooled it
- Systematic review of post-COVID condition in Nordic population-based registry studies.Nature communications · 2025Pooled it
- The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews.Frontiers in medicine · 2025Pooled it
- Identifying COVID-19 variant through symptoms profile: Would it be possible? A rapid review.BMC infectious diseases · 2024Pooled it
- Disease severity among hospitalized children during the COVID-19 pandemic in Israel.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The impact of policy restrictions and mobility changes on excess mortality during the COVID-19 pandemic in The Netherlands, 2020-2022.PloS one · 2026Article
- A retrospective risk factor analysis in psychiatric inpatients with COVID-19 from 2020 to 2023 at a neuropsychiatric hospital in Tokyo.PCN reports : psychiatry and clinical neurosciences · 2025Article
- A public health perspective of SARS-CoV-2 evolution and surveillance strategies in Germany from 2020 to 2023.Communications medicine · 2025Review
- Pediatric COVID-19 severity by SARS-CoV-2 lineage and vaccine status in Canada: an IMPACT study.Pediatric research · 2025Article
- Organizing pneumonia in hospitalized COVID-19 patients: risk factors and long-term outcomes.Pneumonia (Nathan Qld.) · 2025Article
- Effects of coronavirus severity and vaccination numbers on postsurgical mortality for elective surgical procedures in the VA population.ANZ journal of surgery · 2025Article
- Human coronaviruses: activation and antagonism of innate immune responses.Microbiology and molecular biology reviews : MMBR · 2025Review
- Quantitatively analyzing the relationship between non-pharmaceutical interventions and the direction of virus evolution using a dynamic model.Frontiers in public health · 2025Article
- Comparison of COVID-19-associated inpatient burden by variant period in hospitalized children age <5 years in the United States.Frontiers in pediatrics · 2025Article
- Enhanced predictability and interpretability of COVID-19 severity based on SARS-CoV-2 genomic diversity: a comprehensive study encompassing four years of data.Scientific reports · 2024Article
- Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19.European stroke journal · 2024Article
- Prediction of Clinical Severity of COVID-19 Using a Combination of Heparin-Binding Protein, Interleukin-6, and C-Reactive Protein: A Retrospective Study.The clinical respiratory journal · 2024Article
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- Socioeconomic Inequalities in SARS-CoV-2 Infection and COVID-19 Health Outcomes in Urban Italy During the COVID-19 Vaccine Rollout, January-November 2021.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the variation in the SARS-CoV-2 virus, COVID-19 exhibits significant variability in severity. This presents challenges for governments in managing the allocation of healthcare resources and prioritizing health interventions. Clinical severity is also a critical statistical parameter for researchers to quantify the risks of infectious disease, model the transmission of COVID-19, and provide some targeted measures to control the pandemic. To obtain more accurate severity estimates, including confirmed case-hospitalization risk, confirmed case-fatality risk, hospitalization-fatality risk, and hospitalization-ICU risk, we conducted a systematic review and meta-analysis on the clinical severity (including hospitalization, ICU, and fatality risks) of different variants during the period of COVID-19 mass vaccination and provided pooled estimates for each clinical severity metric. All searches were carried out on 1 February 2022 in PubMed for articles published from 1 January 2020 to 1 February 2022. After identifying a total of 3536 studies and excluding 3523 irrelevant studies, 13 studies were included. The severity results show that the Delta and Omicron variants have the highest (6.56%, 0.46%, 19.63%, and 9.06%) and lowest severities (1.51%, 0.04%, 6.01%, and 3.18%), respectively, according to the four clinical severity metrics. Adults over 65 have higher severity levels for all four clinical severity metrics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.