ArticlePolymers2023
Surface Topography of PLA Implants Defines the Outcome of Foreign Body Reaction: An In Vivo Study.
Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Molybdenum as a biodegradable bone implant material assessed by ISO 10993-5/-12-compliant cytocompatibility testing and transcriptomic profiling in a human osteoblast cell line.Scientific reports · 2026Article
- Longitudinal in vivo OCT/OCTA of gastric tumor microvasculature via an implantable optical window.Biomedical optics express · 2026Article
- Advanced Design Concepts for Shape-Memory Polymers in Biomedical Applications and Soft Robotics.Polymers · 2026Review
- Development and Pilot in Vivo Testing of a Protocol for PLGA-Vancomycin Coatings on PTFE Used as Silicone-Implant Analogs.Medicina (Kaunas, Lithuania) · 2025Article
- Photothermolysis with 1550 nm Fractional Laser Promotes Regeneration of Gingival Mucosa.Bioengineering (Basel, Switzerland) · 2025Article
- Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics.Materials today. Bio · 2025Review
- A comparative study on the effects of biodegradable high-purity magnesium screw and polymer screw for fixation in epiphyseal trabecular bone.Regenerative biomaterials · 2024Article
- PLLA Coating of Lyophilized Human Bone Allograft for Long-term Release of Antibiotics.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The formation of a dense fibrous capsule around the foreign body and its contracture is the most common complication of biomaterial implantation. The aim of our research is to find out how the surface of the implant influences the inflammatory and fibrotic reactions in the surrounding tissues. We made three types of implants with a remote surface topography formed of polylactide granules with different diameters: large (100-200 µm), medium (56-100 µm) and small (1-56 µm). We placed these implants in skin pockets in the ears of six chinchilla rabbits. We explanted the implants on the 7th, 14th, 30th and 60th days and performed optical coherence tomography, and histological, immunohistochemical and morphometric studies. We examined 72 samples and compared the composition of immune cell infiltration, vascularization, the thickness of the peri-implant tissues, the severity of fibrotic processes and α-SMA expression in myofibroblasts. We analyzed the scattering coefficient of tissue layers on OCT scans. We found that implants made from large granules induced a milder inflammatory process and slower formation of a connective tissue capsule around the foreign body. Our results prove the importance of assessing the surface texture in order to avoid the formation of capsular contracture after implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.