Biomimetic Inorganic Nanovectors as Tumor-Targeting Theranostic Platform against Triple-Negative Breast Cancer.

Huang Wen, Pekka Poutiainen, Enkhzaya Batnasan, Leena Latonen, Vesa-Pekka Lehto, Wujun Xu

Open access · goldAbstract read

In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huang WenDepartment of Technical Physics, University of Eastern Finland, Yliopistonranta 1F, 70211 Kuopio, Finland.ORCID 0000-0002-6294-7465

Pekka PoutiainenKuopio University Hospital, University of Eastern Finland, Puijonlaaksontie 2, 70210 Kuopio, Finland.

Enkhzaya BatnasanSchool of Medicine, University of Eastern Finland, Yliopistonranta 1F, 70211 Kuopio, Finland.

Leena LatonenSchool of Medicine, University of Eastern Finland, Yliopistonranta 1F, 70211 Kuopio, Finland.

Vesa-Pekka LehtoDepartment of Technical Physics, University of Eastern Finland, Yliopistonranta 1F, 70211 Kuopio, Finland.ORCID 0000-0001-8153-1070

Wujun XuDepartment of Technical Physics, University of Eastern Finland, Yliopistonranta 1F, 70211 Kuopio, Finland.

University of Eastern Finland · FI

Funding

Academy of Finland 314412Academy of Finland 356056University of Eastern Finland 29980041

6 · The paper itself

Abstract

Mesoporous silicon nanoparticles (PSi NPs) are promising platforms of nanomedicine because of their good compatibility, high payload capacities of anticancer drugs, and easy chemical modification. Here, PSi surfaces were functionalized with bisphosphonates (BP) for radiolabeling, loaded with doxorubicin (DOX) for chemotherapy, and the NPs were coated with cancer cell membrane (CCm) for homotypic cancer targeting. To enhance the CCm coating, the NP surfaces were covered with polyethylene glycol prior to the CCm coating. The effects of the BP amount and pH conditions on the radiolabeling efficacy were studied. The maximum BP was (2.27 wt%) on the PSi surfaces, and higher radiochemical yields were obtained for

Indexed as

bisphosphonatescancer cell membrane coatingdoxorubicinmesoporous silicon nanoparticlesradiolabelingtriple-negative breast cancer

Identifiers

PMID37896267

DOI10.3390/pharmaceutics15102507

PMCPMC10610067

OpenAlexW4387877051

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.