Evidence map›Paper›PMID 37896185›Full record

ArticlePharmaceutics2023

Antiproliferative Imidazo-Pyrazole-Based Hydrogel: A Promising Approach for the Development of New Treatments for PLX-Resistant Melanoma.

Silvana Alfei, Marco Milanese, Chiara Brullo, Giulia Elda Valenti, Cinzia Domenicotti, Eleonora Russo, Barbara Marengo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Triazole-imidazo[1,2-International journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Silvana AlfeiSection of Chemistry and Pharmaceutical and Food Technologies, Department of Pharmacy, University of Genoa, Viale Cembrano, 4, 16148 Genoa, Italy.ORCID 0000-0002-4630-4371
Marco MilaneseSection of Chemistry and Pharmaceutical and Food Technologies, Department of Pharmacy, University of Genoa, Viale Cembrano, 4, 16148 Genoa, Italy.ORCID 0000-0003-3384-0666
Chiara BrulloSection of Medicinal Chemistry and Cosmetic Product, Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.ORCID 0000-0002-2575-7726
Giulia Elda ValentiDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0001-7077-7534
Cinzia DomenicottiDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0002-5003-7333
Eleonora RussoSection of Medicinal Chemistry and Cosmetic Product, Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.ORCID 0000-0002-5856-7929
Barbara MarengoDepartment of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0003-3056-6569
University of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aiming at developing a dermal formulation against melanoma, the synthesized imidazo-pyrazoles 2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-7-carboxylic acid (3-methoxy-4-phenoxy-benzylidene)-hydrazide (

Indexed as

cationic polystyrene-based resin (R4)high equilibrium degree of swelling (EDS)high equilibrium water content (EWC)imidazo-pyrazoles (IPs)low yield stressPLX-resistant melanomapseudoplastic rheological behaviorself-formed composite hydrogelshear thinning

Identifiers

PMID37896185
PMCPMC10610107
OpenAlexW4387373045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.