Evidence map›Paper›PMID 37896176›Full record

ReviewPharmaceutics2023

The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health.

Stephen C Emencheta, Chinasa V Olovo, Osita C Eze, Chisom F Kalu, Dinebari P Berebon, Ebele B Onuigbo, Marta M D C Vila, Victor M Balcão, Anthony A Attama

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Stephen C EmenchetaDepartment of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka 410001, Nigeria.ORCID 0000-0002-9579-7029
Chinasa V OlovoDepartment of Microbiology, University of Nigeria, Nsukka 410001, Nigeria.
Osita C EzeDepartment of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka 410001, Nigeria.ORCID 0000-0002-7428-2333
Chisom F KaluDepartment of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka 410001, Nigeria.ORCID 0000-0001-5991-2205
Dinebari P BerebonDepartment of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka 410001, Nigeria.ORCID 0000-0002-3187-3096
Ebele B OnuigboDepartment of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka 410001, Nigeria.
Marta M D C VilaVBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, Brazil.
Victor M BalcãoVBlab-Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba 18023-000, Brazil.ORCID 0000-0003-0772-2834
Anthony A AttamaDepartment of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria.ORCID 0000-0002-5751-2280
University of Nigeria · NGUniversidade de Sorocaba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms to absorb and gain entry into the bacterial cell wall via the release of viral genetic material, which uses the replication mechanisms of the host bacteria to produce and release daughter progeny virions that attack the surrounding host cells. They possess specific characteristics, including specificity for particular or closely related bacterial species. They have many applications, including as potential alternatives to antibiotics against multi-resistant bacterial pathogens and as control agents in bacteria-contaminated environments. They are ubiquitously abundant in nature and have diverse biota, including in the gut. Gut microbiota describes the community and interactions of microorganisms within the intestine. As with bacteria, parasitic bacteriophages constantly interact with the host bacterial cells within the gut system and have obvious implications for human health. However, it is imperative to understand these interactions as they open up possible applicable techniques to control gut-implicated bacterial diseases. Thus, this review aims to explore the interactions of bacteriophages with bacterial communities in the gut and their current and potential impacts on human health.

Indexed as

bacteriophagesgut microbiotahuman healththerapeutic applications

Identifiers

PMID37896176
PMCPMC10609668
OpenAlexW4387310435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.