ArticlePharmaceutics2023
Rheological and Viscoelastic Analysis of Hybrid Formulations for Topical Application.
Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
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- Anti-acne cinnamic acid bigel: a hybrid topical system for concurrent modulation of inflammation and microbial load.Inflammopharmacology · 2026Article
- Characterization, antifungal potential, cytocompatibility, and regenerative potential of mucoadhesive gel containing antifungal-β-cyclodextrin inclusion complexes.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026Article
- Silibinin-Loaded Proniosomal Gel for Cutaneous Application: Pharmaco-Technical Characterization and In Vitro-In Ovo Biocompatibility.Gels (Basel, Switzerland) · 2026Article
- Rheological Properties of Konjac Glucomannan Gels and Their Potential Application in Periodontal Therapy.Gels (Basel, Switzerland) · 2026Article
- Engineering a Nanostructured Hybrid Gel System with Sodium Humate for Enhanced Wound Healing.Journal of functional biomaterials · 2026Article
- In vitro and in vivo evaluation of oleuropein loaded hyalurosomes for diabetic foot ulcer healing.Scientific reports · 2026Article
- A Novel Bioactive Emulgel withGels (Basel, Switzerland) · 2026Article
- Optimization ofACS omega · 2025Article
- Development and Characterization of a Wound-Healing System Based on a Marine Biopolymer.Gels (Basel, Switzerland) · 2025Article
- LaponitePharmaceutics · 2025Article
- Physico-Chemical and Antimicrobial Evaluation of Ozonated Olive Oil Produced with a Medical-Grade Generator for Veterinary Purposes.Microorganisms · 2025Article
- Novel Alkyl-Polyglucoside-Based Topical Creams Containing Basil Essential Oil (Pharmaceutics · 2025Article
- Characterization and Evaluation of the Cytotoxicity of Pregabalin Gels for Oral Application.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The rheological and viscoelastic properties of hybrid formulations composed of vehicles designed for cutaneous topical application and loaded with ultradeformable liposomes (UDL) were assessed. UDL were selected for their established ability to transport both lipophilic and hydrophilic compounds through the skin, and are applicable in pharmaceuticals and cosmetics. Formulations underwent flow analysis and were fitted to the Herschel-Bulkley model due to their prevalent non-Newtonian behavior in most cases. Linear viscoelastic regions (LVR) were identified, and G' and G″ moduli were determined via frequency sweep steps, considering the impact of temperature and aging. The formulations exhibited non-Newtonian behavior with pseudoplastic traits in most cases, with UDL incorporation inducing rheological changes. LVR and frequency sweep tests indicated predominantly elastic solid behavior, with G' higher than G″, at different temperatures and post-production times. Tan δ values also illustrated a predominant solid-like behavior over liquid. This study provides pivotal insights into the rheological and viscoelastic features of topical formulations, emphasizing the crucial role of meticulous vehicle and formulation selection when incorporating UDL or analogous liposomal drug delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.