Evidence map›Paper›PMID 37896138›Full record

ArticlePharmaceutics2023

The Amorphous Solid Dispersion of Chrysin in Plasdone

Chenhui Wang, Xiaowei Liu, Ruihan Zhao, Meiqing Yang, Wenqian Liu, Qiuyang Dai, Xiaofeng Bao, Yong Chen, Jun Ma

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chenhui WangSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Xiaowei LiuSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Ruihan ZhaoSchool of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Meiqing YangSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Wenqian LiuSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Qiuyang DaiSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Xiaofeng BaoSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Yong ChenSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Jun MaShenzhen Wanhe Pharmaceutical Company & Guangdong Provincial Key Laboratory of Microecological Preparations, 7 Huitong Road, Shenzhen 518107, China.
Nantong University · CNChina Pharmaceutical University · CN

Funding

College Student Innovation Training Program of Nantong University 202210304069ZInitiation Project of Shenzhen Engineering Research Center for New Oral Solid Formulations XMHT20220104010Research Program of Guangdong Provincial Key Laboratory of Microecological Preparations 2022B1212020004Science and Technology Funding of Nantong City JC2021117
6 · The paper itself

Abstract

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render its oral bioavailability rather poor. This study aimed to develop a stable solid dispersion formulation of chrysin to improve the dissolution of chrysin, so as to increase its oral bioavailability and improve its antihyperlipidemic activities. A solid dispersion of chrysin was prepared using a solvent evaporation method, with Plasdone

Indexed as

antihyperlipidemic performancechrysindissolutionin-situ perfusionoral bioavailabilitysolid dispersionstabilityXRD

Identifiers

PMID37896138
PMCPMC10610386
OpenAlexW4386996679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.