Evidence map›Paper›PMID 37896131›Full record

ArticlePharmaceutics2023

Tamoxifen-Loaded Eudragit Nanoparticles: Quality by Design Approach for Optimization of Nanoparticles as Delivery System.

Muzna Ali Khattak, Zafar Iqbal, Fazli Nasir, Steven H Neau, Sumaira Irum Khan, Talaya Hidayatullah, Sadia Pervez, Mirina Sakhi, Syeda Rabqa Zainab, Shazma Gohar and 4 more

Abstract read
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In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Formulation andCurrent pharmaceutical design · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Muzna Ali KhattakDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Zafar IqbalDepartment of Pharmacy, Sarhad University of Science and Information Technology, Peshawar 25000, Pakistan.
Fazli NasirDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.ORCID 0000-0002-0893-8883
Steven H NeauPhiladelphia College of Pharmacy, University of Sciences, Philadelphia, PA 19104, USA.
Sumaira Irum KhanPharmacy Department, Faculty of Health and Medical Sciences, Mirpur University of Science and Technology, New Mirpur City 10250, Pakistan.
Talaya HidayatullahDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Sadia PervezDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Mirina SakhiDepartment of Pharmacy, University of Swabi, Swabi 23430, Pakistan.
Syeda Rabqa ZainabDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Shazma GoharDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Fawaz AlasmariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11362, Saudi Arabia.ORCID 0000-0003-2382-5892
Altafur RahmanDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Gul E MaryamDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Arbab TahirDepartment of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.ORCID 0009-0001-7373-2216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles have numerous applications as drug carriers in drug delivery. The aim of the study was to produce tamoxifen nanoparticles with a defined size and higher encapsulation for efficient tissue uptake with controlled drug release. The quality by design approach was utilized to produce tamoxifen-loaded Eudragit nanoparticles by identifying the significant process variables using the nanoprecipitation method. The process variables (amount of drug, polymer, and surfactant) were altered to analyze the influence on particle size (PS), % encapsulation efficiency (EE). The results showed that the drug and polymer individually as well as collectively have an impact on PS, while the surfactant has no impact on the PS. The %EE was influenced by the surfactant individually and in interaction with the drug. The linear regression model was endorsed to fit the data showing high R

Indexed as

design of experimentdrug deliveryEudragit RS 100nanoparticlesresponse surface methodologystatistical analysistamoxifen

Identifiers

PMID37896131
PMCPMC10609841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.