Evidence map›Paper›PMID 37895877›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Formulation and Characterization of Curcumin Niosomes: Antioxidant and Cytotoxicity Studies.

Shazia Akram Ghumman, Amna Ijaz, Sobia Noreen, Afeefa Aslam, Rizwana Kausar, Ali Irfan, Sumera Latif, Gamal A Shazly, Pervaiz Akhtar Shah, Maria Rana and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Enhanced cytotoxic activity ofNanoscale advances · 2026
    Article
  4. Article
  5. In-vivo and in-vitro assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shazia Akram GhummanCollege of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.ORCID 0000-0002-9631-0243
Amna IjazCollege of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Sobia NoreenInstitute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.ORCID 0000-0002-0815-2223
Afeefa AslamAbbottabad Campus, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Rizwana KausarILM College of Pharmaceutical Sciences, Sargodha 40100, Pakistan.
Ali IrfanDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0002-8977-3303
Sumera LatifInstitute of Pharmacy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University, Lahore 54000, Pakistan.
Gamal A ShazlyDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Pervaiz Akhtar ShahUniversity College of Pharmacy, University of the Punjab, Lahore 54590, Pakistan.
Maria RanaRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore 54000, Pakistan.
Asma AslamCollege of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Momina AltafCollege of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Katarzyna Kotwica-MojzychLaboratory of Experimental Cytology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.ORCID 0000-0002-3655-7324
Yousef A Bin JardanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-3302-4036

Funding

This research is supported by the Researchers Supporting Project Number (RSP2023R457), King Saud University, Riyadh, Saudi Arabia. RSP2023R457
6 · The paper itself

Abstract

Curcumin's applications in the treatment of conditions including osteoarthritis, dementia, malignancies of the pancreas, and malignancies of the intestines have drawn increasing attention. It has several wonderful qualities, including being an anti-inflammatory agent, an anti-mutagenic agent, and an antioxidant, and has substantially reduced inherent cytotoxicity outcomes. Although curcumin possesses multiple known curative properties, due to its limited bioavailability, it is necessary to develop efficient strategies to overcome these hurdles. To establish an effective administration method, various niosomal formulations were optimized using the Box-Behnken design and assessed in the current investigation. To examine the curcumin niosomes, zeta sizer, zeta potential, entrapment efficiency, SEM, antioxidant potential, cytotoxicity, and release studies were performed. The optimized curcumin niosomes exhibited an average particle size of 169.4 nm, a low PDI of 0.189, and high entrapment efficiency of 85.4%. The release profile showed 79.39% curcumin after 24 h and had significantly higher antioxidant potential as compared with that of free curcumin. The cytotoxicity results of curcumin niosomes presented increased mortality in human ovarian cancer A2780.

Indexed as

antioxidantBox–Behnkencurcumincytotoxicityniosomesovarian cancer

Identifiers

PMID37895877
PMCPMC10610541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.