Evidence map›Paper›PMID 37895857›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid.

Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D'Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D'Urzo, Emiliano Chiarot and 4 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Valeria CafaroDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-6686-7657
Andrea BossoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-2360-300X
Ilaria Di NardoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Assunta D'AmatoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0001-9246-5523
Irene IzzoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-0369-0102
Francesco De RiccardisDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-8121-9463
Marialuisa SiepiDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Rosanna CulurcielloDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Nunzia D'UrzoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Emiliano ChiarotGSK, 53100 Siena, Italy.
Antonina TorreGSK, 53100 Siena, Italy.
Elio PizzoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-3652-8865
Marcello MerolaDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-4298-4015
Eugenio NotomistaDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
University of Naples Federico II · ITUniversity of Salerno · IT

Funding

Italian Cystic Fibrosis Research Foundation (in collaboration with "Delegazione FFC di Imola e Romagna") FFC#18/2018Ministero dell'Università e della Ricerca (MUR) P2022ZBNC2Ministero dell'Università e della Ricerca (MUR) PRIN 2020AEX4TAUniversity of Salerno FARB
6 · The paper itself

Abstract

Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens, but they are limited by their susceptibility to proteolytic degradation. An intriguing solution to this issue could be the development of functional mimics of CAMPs with structures that enable the evasion of proteases. Peptoids (

Indexed as

antimicrobial peptidebiofilmESKAPE pathogensmultidrug resistancepeptidomimeticpeptoid

Identifiers

PMID37895857
PMCPMC10610514
OpenAlexW4387230442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.