Evidence map›Paper›PMID 37895813›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Development of Osthole-Loaded Microemulsions as a Prospective Ocular Delivery System for the Treatment of Corneal Neovascularization: In Vitro and In Vivo Assessments.

Yali Zhang, Jingjing Yang, Yinjian Ji, Zhen Liang, Yuwei Wang, Junjie Zhang

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yali ZhangThe First of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Jingjing YangOphthalmology Department, Henan Provincial People's Hospital, Henan Eye Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Yinjian JiThe First of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhen LiangOphthalmology Department, Henan Provincial People's Hospital, Henan Eye Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Yuwei WangThe First of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Junjie ZhangOphthalmology Department, Henan Provincial People's Hospital, Henan Eye Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
First Affiliated Hospital of Henan University · CNHenan Provincial People's Hospital · CNZhengzhou University · CN

Funding

Henan Eye Hospital Basic Science Research Program 22JCQN008Scientific research of traditional Chinese medicine in Henan province 2023ZY2045
6 · The paper itself

Abstract

Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded microemulsion (OST-ME) was created to improve the drug's therapeutic effect on CNV after topical administration. The OST-ME formulation comprised Capryol-90 (CP-90), Cremophor

Indexed as

corneal neovascularizationmicroemulsionocular drug delivery systemostholepharmacokinetic

Identifiers

PMID37895813
PMCPMC10610237
OpenAlexW4386996332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.