Evidence map›Paper›PMID 37895198›Full record

ReviewGenes2023

Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing's Sarcoma: A Composite Review.

Mubashir Hassan, Saba Shahzadi, Amal Malik, Salah Ud Din, Muhammad Yasir, Wanjoo Chun, Andrzej Kloczkowski

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Mubashir HassanThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USA.
Saba ShahzadiThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USA.
Amal MalikInstitute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54590, Pakistan.
Salah Ud DinDepartment of Bioinformatics, University of Okara, Okara 56130, Pakistan.
Muhammad YasirDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
Wanjoo ChunDepartment of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-1984-3545
Andrzej KloczkowskiThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-1002-5095
Kangwon National University · KRThe Ohio State University · USUniversity of Lahore · PKUniversity of Okara · PK

Funding

Novel Use of Genome Information to Understand MutationsR01HG012117 · NHGRI · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L, KLOCZKOWSKI, ANDRZEJ · 2021 to 2025
$2.3M
Protein Sequence MatchingR01GM127701 · NIGMS · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L, KLOCZKOWSKI, ANDRZEJ · 2018 to 2021
$1.4M
NHGRI NIH HHS R01 HG012117NIGMS NIH HHS R01 GM127701
6 · The paper itself

Abstract

Ewing's sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and prognostic biomarkers in various cancers. Furthermore, microRNAs have shown to be a good therapeutic agent due to their involvement in the dysregulation of various molecular pathways linked to tumour progression, invasion, angiogenesis, and metastasis. In this review, comprehensive data mining was employed to explore various microRNAs that might have therapeutic potential as target molecules in the treatment of ES.

Indexed as

Bone NeoplasmsMicroRNAsSarcoma, EwingChildHumansYoung AdultMicroRNAsEwing’s sarcomaEWSR1miRNAtherapeutic targets

Identifiers

PMID37895198
PMCPMC10606885
OpenAlexW4386996591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.