Evidence map›Paper›PMID 37895189›Full record

ArticleGenes2023

Implementation of Pharmacogenetics in First-Line Care: Evaluation of Its Use by General Practitioners.

Denise van der Drift, Mirjam Simoons, Birgit C P Koch, Gemma Brufau, Patrick Bindels, Maja Matic, Ron H N van Schaik

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Denise van der DriftDepartment of Clinical Chemistry, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Mirjam SimoonsDepartment of Hospital Pharmacy, Erasmus MC University Medical Center, 3015 CN Rotterdam, The Netherlands.
Birgit C P KochDepartment of Hospital Pharmacy, Erasmus MC University Medical Center, 3015 CN Rotterdam, The Netherlands.
Gemma BrufauDepartment of Clinical Chemistry, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Patrick BindelsDepartment of General Practice, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Maja MaticDepartment of Clinical Chemistry, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-1316-2888
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacogenetics (PGx) can explain/predict drug therapy outcomes. There is, however, unclarity about the use and usefulness of PGx in primary care. In this study, we investigated PGx tests ordered by general practitioners (GPs) in 2021 at Dept. Clinical Chemistry, Erasmus MC, and analyzed the gene tests ordered, drugs/drug groups, reasons for testing and single-gene versus panel testing. Additionally, a survey was sent to 90 GPs asking about their experiences and barriers to implementing PGx. In total, 1206 patients and 6300 PGx tests were requested by GPs.

Indexed as

Drug-Related Side Effects and Adverse ReactionsGeneral PractitionersAntidepressive AgentsGenetic TestingHumansPharmacogeneticsAntidepressive Agentsclinical implementationCYP450GPpersonalized medicinepharmacogeneticspharmacogenomics

Identifiers

PMID37895189
PMCPMC10606701
OpenAlexW4386996689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.