Evidence map›Paper›PMID 37895183›Full record

ArticleGenes2023

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer's Disease and Thirteen Cardiovascular Traits.

Yury Loika, Elena Loiko, Irina Culminskaya, Alexander M Kulminski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Inhaled Pollutants of the Gero-Exposome and Later-Life Health.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yury LoikaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-6730-7320
Elena LoikoBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Irina CulminskayaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.
Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-0205-8228
Social Science Research Council · US

Funding

ApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9M
Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseasesR01AG065477 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2020 to 2024
$3.8M
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic contextR01AG070488 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M, OUKRAINTSEVA, SVETLANA V. · 2020 to 2024
$2.8M
NIA NIH HHS R01 AG061853NIA NIH HHS R01 AG065477NIA NIH HHS R01AG065477NIA NIH HHS R01 AG070488NIA NIH HHS R01AG070488
6 · The paper itself

Abstract

Alzheimer's disease (AD) and cardiovascular traits might share underlying causes. We sought to identify clusters of cardiovascular traits that share genetic factors with AD. We conducted a univariate exome-wide association study and pair-wise pleiotropic analysis focused on AD and 16 cardiovascular traits-6 diseases and 10 cardio-metabolic risk factors-for 188,260 UK biobank participants. Our analysis pinpointed nine genetic markers in the

Indexed as

Alzheimer DiseaseCardiovascular DiseasesCholesterolDNA HelicasesExomeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansNuclear ProteinsPhenotypeTranscription FactorsCholesterolDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription FactorsagingAlzheimer’s diseasecardio-metabolic traitscoronary heart diseaseexome-wide association studyheart failurehierarchical cluster analysismyocardial infarctionpleiotropystroke

Identifiers

PMID37895183
PMCPMC10606283
OpenAlexW4386962907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.