Evidence map›Paper›PMID 37895181›Full record

Observational studyGenes2023

Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images.

Federico Greco, Andrea Panunzio, Alessandro Tafuri, Caterina Bernetti, Vincenzo Pagliarulo, Bruno Beomonte Zobel, Arnaldo Scardapane, Carlo Augusto Mallio

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Federico GrecoDepartment of Radiology, Cittadella Della Salute, Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi, 2, 73100 Lecce, Italy.ORCID 0000-0002-9477-0238
Andrea PanunzioDepartment of Urology, "Vito Fazzi" Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, Italy.ORCID 0000-0002-9756-4632
Alessandro TafuriDepartment of Urology, "Vito Fazzi" Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, Italy.
Caterina BernettiDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.
Vincenzo PagliaruloDepartment of Urology, "Vito Fazzi" Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, Italy.
Bruno Beomonte ZobelDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.
Arnaldo ScardapaneDipartimento Interdisciplinare di Medicina, Sezione di Diagnostica Per Immagini, Università degli Studi di Bari "Aldo Moro", Piazza Giulio Cesare, 11, 70124 Bari, Italy.ORCID 0000-0002-6116-5701
Carlo Augusto MallioDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.ORCID 0000-0002-0149-0801
Ospedale Vito Fazzi · ITUniversità Campus Bio-Medico · ITASL Roma · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GTPases of immunity-associated proteins (GIMAP) genes include seven functional genes and a pseudogene. Most of the GIMAPs have a role in the maintenance and development of lymphocytes. GIMAPs could inhibit the development of tumors by increasing the amount and antitumor activity of infiltrating immunocytes. Knowledge of key factors that affect the tumor immune microenvironment for predicting the efficacy of immunotherapy and establishing new targets in ccRCC is of great importance. A computed tomography (CT)-based radiogenomic approach was used to detect the imaging phenotypic features of GIMAP family gene expression in ccRCC. In this retrospective study we enrolled 193 ccRCC patients divided into two groups: ccRCC patients with GIMAP expression (

Indexed as

Carcinoma, Renal CellKidney NeoplasmsHumansRetrospective StudiesTomography, X-Ray ComputedTumor Microenvironmentclear cell renal cell carcinomacomputed tomographygenesGIMAPimagingimmunocytesimmunotherapyprecision medicineradiogenomicsradiologic features

Identifiers

PMID37895181
PMCPMC10606653
OpenAlexW4386962920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.