Evidence map›Paper›PMID 37895118›Full record

ArticleInternational journal of molecular sciences2023

The Problem with Inventing Molecular Mechanisms to Fit Thermodynamic Equations of Muscle.

Josh Baker

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Scaling in Biological Systems: A Molecular-Ensemble Duality.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Four phases of a force transient emerge from a binary mechanical system.Journal of muscle research and cell motility · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Josh BakerSchool of Medicine, University of Nevada, Reno, Reno, NV 89557, USA.
University of Nevada, Reno · US

Funding

A Multi-Scale Study of the Interplay Between Force Generating and Force Sensing MR01HL090938 · NHLBI · UNIVERSITY OF NEVADA RENO · PI BAKER, JONATHAN E. · 2008 to 2011
$1.3M
NHLBI NIH HHS R01 HL090938
6 · The paper itself

Abstract

Almost every model of muscle contraction in the literature to date is a molecular power stroke model, even though this corpuscular mechanism is opposed by centuries of science, by 85 years of unrefuted evidence that muscle is a thermodynamic system, and by a quarter century of direct observations that the molecular mechanism of muscle contraction is a molecular switch, not a molecular power stroke. An ensemble of molecular switches is a binary mechanical thermodynamic system from which A.V. Hill's muscle force-velocity relationship is directly derived, where Hill's parameter

Indexed as

Models, BiologicalMuscle ContractionActinsMuscle, SkeletalThermodynamicsActinsactinforcefree energykineticsmechanicsmotormusclemyosinparadigmthermodynamics

Identifiers

PMID37895118
PMCPMC10607768
OpenAlexW4387860266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.