Evidence map›Paper›PMID 37895100›Full record

ArticleInternational journal of molecular sciences2023

New Flexible Analogues of 8-Aza-7-deazapurine Nucleosides as Potential Antibacterial Agents.

Anastasia Khandazhinskaya, Barbara Eletskaya, Anton Mironov, Irina Konstantinova, Olga Efremenkova, Sofya Andreevskaya, Tatiana Smirnova, Larisa Chernousova, Evgenia Kondrashova, Alexander Chizhov and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Anastasia KhandazhinskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991 Moscow, Russia.ORCID 0000-0003-1452-0253
Barbara EletskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 Moscow, Russia.ORCID 0000-0002-9552-7141
Anton MironovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 Moscow, Russia.
Irina KonstantinovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 Moscow, Russia.
Olga EfremenkovaGause Institute of New Antibiotics, Bol'shaya Pirogovskaya St. 11, 119021 Moscow, Russia.ORCID 0000-0003-3131-1031
Sofya AndreevskayaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, 107564 Moscow, Russia.
Tatiana SmirnovaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, 107564 Moscow, Russia.
Larisa ChernousovaCentral Tuberculosis Research Institute, 2 Yauzskaya Alley, 107564 Moscow, Russia.
Evgenia KondrashovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991 Moscow, Russia.
Alexander ChizhovZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, 119991 Moscow, Russia.
Katherine Seley-RadtkeDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.ORCID 0000-0002-0154-3459
Sergey KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991 Moscow, Russia.ORCID 0000-0002-7443-6961
Elena MatyuginaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St. 32, 119991 Moscow, Russia.ORCID 0000-0002-4981-7316
Engelhardt Institute of Molecular Biology · RUCentral Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences · RUInstitute of Bioorganic Chemistry · RUGause Institute of New Antibiotics Russian Academy of Medical Sciences · RUN.D. Zelinsky Institute of Organic Chemistry · RUPeoples' Friendship University of Russia · RUUniversity of Maryland, Baltimore County · US

Funding

Russian Science Foundation 19-74-10048
6 · The paper itself

Abstract

A variety of ribo-, 2'-deoxyribo-, and 5'-norcarbocyclic derivatives of the 8-aza-7-deazahypoxanthine fleximer scaffolds were designed, synthesized, and screened for antibacterial activity. Both chemical and chemoenzymatic methods of synthesis for the 8-aza-7-deazainosine fleximers were compared. In the case of the 8-aza-7-deazahypoxanthine fleximer, the transglycosylation reaction proceeded with the formation of side products. In the case of the protected fleximer base, 1-(4-benzyloxypyrimidin-5-yl)pyrazole, the reaction proceeded selectively with formation of only one product. However, both synthetic routes to realize the fleximer ribonucleoside (

Indexed as

Mycobacterium tuberculosisTuberculosisAnti-Bacterial AgentsGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsNucleosidesPurinesPyrazolesStructure-Activity Relationship7-deazapurineAnti-Bacterial AgentsNucleosidesPurinesPyrazolesantibacterial activityantituberculosis activityfleximerinhibitornucleoside analogues

Identifiers

PMID37895100
PMCPMC10607158
OpenAlexW4387843823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.