Evidence map›Paper›PMID 37895076›Full record

ArticleInternational journal of molecular sciences2023

Association of HLA-A*11:01, -A*24:02, and -B*18:01 with Prostate Cancer Risk: A Case-Control Study.

Maria Antonietta Manca, Elena Rita Simula, Davide Cossu, Tatiana Solinas, Massimo Madonia, Roberto Cusano, Leonardo Antonio Sechi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Antonietta MancaDipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy.
Elena Rita SimulaDipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8946-2679
Davide CossuDipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy.ORCID 0000-0002-0557-9467
Tatiana SolinasDipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, 07100 Sassari, Italy.
Massimo MadoniaDipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, 07100 Sassari, Italy.
Roberto CusanoCRS4, Pula, 09100 Cagliari, Italy.
Leonardo Antonio SechiDipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy.ORCID 0000-0003-0566-2049
University of Sassari · ITCenter for Advanced Studies Research and Development in Sardinia · IT

Funding

MUR, PRIN 2022 n: 2022BP837R to LASRegione Autonoma della Sardegna legge regionale 12 22 Dicembre 2022 n. 22 to LAS
6 · The paper itself

Abstract

The major histocompatibility complex (MHC) loci, the most polymorphic regions within the human genome, encode protein complexes responsible for antigen presentation and CD4+ and CD8+ cell activation. In prostate cancer (PCa), the second most diagnosed cancer in the male population, MHC loci undergo significant changes in their expression patterns, which affect the ability of the immune system to attack and eliminate malignant cells. The purpose of this study was to explore the genetic diversity of human leukocyte antigen (HLA)-A and HLA-B in patients with PCa and healthy controls (HCs) by performing HLA genotyping using NGS technology. The analysis highlighted statistically significant differences (

Indexed as

HLA-A AntigensNeoplasmsAllelesCase-Control StudiesHaplotypesHistocompatibility AntigensHLA-B AntigensHumansMajor Histocompatibility ComplexMaleHistocompatibility AntigensHLA-A AntigensHLA-B AntigensHLA-A*11:01HLA-A*24:02HLA-B*18:01prostate cancer

Identifiers

PMID37895076
PMCPMC10607162
OpenAlexW4387813122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.