Evidence map›Paper›PMID 37895063›Full record

ArticleInternational journal of molecular sciences2023

Obtaining New Candidate Peptides for Biological Anticancer Drugs from Enzymatic Hydrolysis of Human and Bovine Hemoglobin.

Ahlam Outman, Mohamed Bouhrim, Codjo Hountondji, Omar M Noman, Ali S Alqahtani, Bernard Gressier, Naïma Nedjar, Bruno Eto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ahlam OutmanLaboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, 3, rue du Professeur Laguesse, B.P. 83, 59000 Lille, France.
Mohamed BouhrimLaboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, 3, rue du Professeur Laguesse, B.P. 83, 59000 Lille, France.
Codjo HountondjiLaboratoire Enzymologie de l'ARN (UR6-UPMC), Université Paris Sorbonne, 75252 Paris, France.
Omar M NomanDepartment of Pharmacognosy, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-0902-6381
Ali S AlqahtaniDepartment of Pharmacognosy, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-1034-7441
Bernard GressierLaboratory of Pharmacology, Pharmacokinetics, and Clinical Pharmacy, Faculty of Pharmaceutical and Biological Sciences, University of Lille, 3, rue du Professeur Laguesse, B.P. 83, 59000 Lille, France.
Naïma NedjarUMR Transfrontalière BioEcoAgro N_1158, Institut Charles Viollette, National Research Institute for Agriculture, Food and the Environment-Université Liège, UPJV, YNCREA, Université Artois, Université Littoral Côte d'Opale, Université Lille, 59000 Lille, France.
Bruno EtoLaboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, 3, rue du Professeur Laguesse, B.P. 83, 59000 Lille, France.
Université de Lille · FRInstitut Charles Viollette · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enzymatic hydrolysis of bovine and human hemoglobin generates a diversity of bioactive peptides, mainly recognized for their antimicrobial properties. However, antimicrobial peptides stand out for their ability to specifically target cancer cells while preserving rapidly proliferating healthy cells. This study focuses on the production of bioactive peptides from hemoglobin and evaluates their anticancer potential using two distinct approaches. The first approach is based on the use of a rapid screening method aimed at blocking host cell protein synthesis to evaluate candidate anticancer peptides, using

Indexed as

Anti-Infective AgentsAntineoplastic AgentsHemoglobinsHumansHydrolysisPeptidesProtein HydrolysatesRNA, TransferAnti-Infective AgentsAntineoplastic AgentsHemoglobinsPeptidesProtein HydrolysatesRNA, Transferbioactive peptidesbovine hemoglobin bovineenzymatic hydrolysishuman hemoglobinmedicine candidate anticancerscreening

Identifiers

PMID37895063
PMCPMC10607105
OpenAlexW4387819501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.