Evidence map›Paper›PMID 37895062›Full record

ArticleInternational journal of molecular sciences2023

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion.

Elisa Franzi, Gregory Mathez, Soraya Dinant, Charlotte Deloizy, Laurent Kaiser, Caroline Tapparel, Ronan Le Goffic, Valeria Cagno

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Elisa FranziInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Gregory MathezInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-4453-7649
Soraya DinantINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, France.ORCID 0009-0000-4383-4353
Charlotte DeloizyINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Laurent KaiserLaboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, University of Geneva, 1206 Geneva, Switzerland.
Caroline TapparelDepartment of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, Switzerland.ORCID 0000-0002-0411-6567
Ronan Le GofficINRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Valeria CagnoInstitute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-5597-334X
Université de Versailles Saint-Quentin-en-Yvelines · FRUniversity of Lausanne · CHUniversity of Geneva · CH

Funding

Swiss National Science Foundation PZ00P3_193289
6 · The paper itself

Abstract

Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment.

Indexed as

Estrogens, Non-SteroidalInfluenza, HumanOrthomyxoviridaeOrthomyxoviridae InfectionsAntiviral AgentsHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansAntiviral AgentsEstrogens, Non-SteroidalHemagglutinin Glycoproteins, Influenza VirusHemagglutininsantiviralentryestrogenshemagglutinininfluenza virusscreening

Identifiers

PMID37895062
PMCPMC10607366
OpenAlexW4387773490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.