Evidence map›Paper›PMID 37895058›Full record

ArticleInternational journal of molecular sciences2023

Ionic Mechanisms of Propagated Repolarization in a One-Dimensional Strand of Human Ventricular Myocyte Model.

Yukiko Himeno, Yixin Zhang, Suzuka Enomoto, Hiroto Nomura, Natsuki Yamamoto, Shotaro Kiyokawa, Mirei Ujihara, Yuttamol Muangkram, Akinori Noma, Akira Amano

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yukiko HimenoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.ORCID 0000-0002-6858-8475
Yixin ZhangDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Suzuka EnomotoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Hiroto NomuraDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Natsuki YamamotoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Shotaro KiyokawaDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Mirei UjiharaDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Yuttamol MuangkramDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Akinori NomaDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Akira AmanoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan.
Ritsumeikan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although repolarization has been suggested to propagate in cardiac tissue both theoretically and experimentally, it has been challenging to estimate how and to what extent the propagation of repolarization contributes to relaxation because repolarization only occurs in the course of membrane excitation in normal hearts. We established a mathematical model of a 1D strand of 600 myocytes stabilized at an equilibrium potential near the plateau potential level by introducing a sustained component of the late sodium current (

Indexed as

Heart VentriclesMyocytes, CardiacAction PotentialsHumansModels, TheoreticalSodiumSodiumearly afterdepolarizationhuman ventricular myocytelate sodium currentmathematical 1D strand modelrepolarization propagation

Identifiers

PMID37895058
PMCPMC10607672
OpenAlexW4387772887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.