Evidence map›Paper›PMID 37895017›Full record

ArticleInternational journal of molecular sciences2023

Nanoform of Phospholipid Composition: Investigation of the Morphological Features by Atomic Force Microscopy.

Sergey V Kraevsky, Irina A Ivanova, Sergey L Kanashenko, Ivan D Shumov, Ilya A Ryazantsev, Yulia A Tereshkina, Lyubov V Kostryukova, Yulia A Romashova, Tatyana O Pleshakova

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sergey V KraevskyInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Irina A IvanovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Sergey L KanashenkoInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Ivan D ShumovInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.ORCID 0000-0002-9795-7065
Ilya A RyazantsevInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Yulia A TereshkinaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Lyubov V KostryukovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.ORCID 0000-0002-1607-2936
Yulia A RomashovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Tatyana O PleshakovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.ORCID 0000-0003-3217-9095

Funding

The Ministry of Education and Science of the Russian Federation 075-15-2021-933
6 · The paper itself

Abstract

Morphological features of the nanoform of a phospholipid composition (NFPh), which can be used as an individual pharmaceutic agent or as a platform for designing drug delivery systems, have been studied using atomic force microscopy (AFM). NFPh has been developed, and its characteristics have been investigated using conventional drug analysis methods, including the determination of the mean diameter of nanosized vesicles in the emulsion via dynamic light scattering (DLS). Using DLS, the mean diameter of the vesicles was found to be ~20 nm. AFM imaging of the surface has revealed four types of objects related to NFPh: (1) compact objects; (2) layer fragments; (3) lamellar structures; and (4) combined objects containing the compact and extended parts. For type (4) objects, it has been found that the geometric ratio of the volume of the convex part to the total area of the entire object is constant. It has been proposed that these objects formed owing to fusion of vesicles of the same size (with the same surface-to-volume ratio). It has been shown that this is possible for vesicles with diameters of 20 nm. This diameter is in good coincidence with the value obtained using DLS.

Indexed as

PhospholipidsDynamic Light ScatteringMicroscopy, Atomic ForcePhospholipidsatomic force microscopydynamic light scatteringnanophospholipid compositionphosphatidylcholinephospholipid membranevesicle

Identifiers

PMID37895017
PMCPMC10607005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.