Evidence map›Paper›PMID 37894987›Full record

ArticleInternational journal of molecular sciences2023

Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes.

Noemi Toth, Xiao-Hua Zhang, Alexandra Zamaro, Martin Morad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Characterization of cardiac disease-associated mutations in RyR2 CaAmerican journal of physiology. Cell physiology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Noemi TothCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Xiao-Hua ZhangCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Alexandra ZamaroCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.ORCID 0000-0002-9938-7203
Martin MoradCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.
Medical University of South Carolina · US

Funding

Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesR01HL153504 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL153504NIH HHS 1R01HL153504-01A1
6 · The paper itself

Abstract

Type-2 ryanodine receptor (RyR2) is the major Ca

Indexed as

Calcium SignalingInduced Pluripotent Stem CellsArrhythmias, CardiacCalciumHumansMutationMyocytes, CardiacRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumCalciumRyanodine Receptor Calcium Release ChannelRyR2 protein, humanCa2+ release deficiencyCa2+ sparkCICRCRISPR/Cas9hiPSC-CMsRyR2 Ca2+ signalingS4938F mutation

Identifiers

PMID37894987
PMCPMC10607246
OpenAlexW4387738116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.