Evidence map›Paper›PMID 37894956›Full record

ArticleInternational journal of molecular sciences2023

Verbascoside Elicits Its Beneficial Effects by Enhancing Mitochondrial Spare Respiratory Capacity and the Nrf2/HO-1 Mediated Antioxidant System in a Murine Skeletal Muscle Cell Line.

Francesca Sciandra, Patrizia Bottoni, Marinella De Leo, Alessandra Braca, Andrea Brancaccio, Manuela Bozzi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 16 citations in OpenAlex.

  1. Coumarins in hypertension management: from vascular signaling pathways to clinical perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Review
  3. Review
  4. Antioxidant and Anti-Inflammatory Properties ofAntioxidants (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Verbascoside-richFrontiers in bioengineering and biotechnology · 2026
    Article
  9. Article
  10. Stress-Induced Secondary Metabolite Profiling inInternational journal of molecular sciences · 2025
    Article
  11. Review
  12. Article
  13. Food chemistry: X · 2024
    Article
  14. Article
  15. International journal of molecular sciences · 2024
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Francesca SciandraIstituto di Scienze e Tecnologie Chimiche "Giulio Natta"-SCITEC Sede di Roma, Largo F. Vito, 00168 Roma, Italy.ORCID 0000-0002-2123-1516
Patrizia BottoniDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Biochimica, Università Cattolica del Sacro Cuore di Roma, Largo F. Vito 1, 00168 Roma, Italy.ORCID 0000-0001-5427-8903
Marinella De LeoDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.ORCID 0000-0002-5544-8457
Alessandra BracaDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.ORCID 0000-0002-9838-0448
Andrea BrancaccioIstituto di Scienze e Tecnologie Chimiche "Giulio Natta"-SCITEC Sede di Roma, Largo F. Vito, 00168 Roma, Italy.ORCID 0000-0003-4690-8826
Manuela BozziIstituto di Scienze e Tecnologie Chimiche "Giulio Natta"-SCITEC Sede di Roma, Largo F. Vito, 00168 Roma, Italy.
Università Cattolica del Sacro Cuore · ITUniversity of Pisa · ITIstituto di Scienze e Tecnologie Chimiche "Giulio Natta"University of Bristol · GB

Funding

Catholic University of Roma Linea D1, 2018, R4124500660 to M.B
6 · The paper itself

Abstract

Muscle weakness and muscle loss characterize many physio-pathological conditions, including sarcopenia and many forms of muscular dystrophy, which are often also associated with mitochondrial dysfunction. Verbascoside, a phenylethanoid glycoside of plant origin, also named acteoside, has shown strong antioxidant and anti-fatigue activity in different animal models, but the molecular mechanisms underlying these effects are not completely understood. This study aimed to investigate the influence of verbascoside on mitochondrial function and its protective role against H

Indexed as

AntioxidantsNF-E2-Related Factor 2AnimalsCell LineGlucosidesHeme Oxygenase-1Hydrogen PeroxideMiceMitochondriaMuscle Fibers, SkeletalMuscle WeaknessPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPolyphenolsReactive Oxygen SpeciesSignal TransductionacteosideAntioxidantsGlucosidesHeme Oxygenase-1Hydrogen PeroxideNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPolyphenolsReactive Oxygen Speciesacteosideantioxidant responseheme oxygenase-1 (HO-1)mitochondrianuclear factor erythroid 2-related factor (Nrf2)peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)skeletal musclespare respiratory capacityverbascoside

Identifiers

PMID37894956
PMCPMC10607197
OpenAlexW4387706810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.