Evidence map›Paper›PMID 37894906›Full record

ArticleInternational journal of molecular sciences2023

Gene Augmentation of CHM Using Non-Viral Episomal Vectors in Models of Choroideremia.

Lyes Toualbi, Maria Toms, Patrick Vingadas Almeida, Richard Harbottle, Mariya Moosajee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lyes ToualbiDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Maria TomsDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.
Patrick Vingadas AlmeidacDNA Vector Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Richard HarbottlecDNA Vector Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Mariya MoosajeeDevelopment, Ageing and Disease, UCL Institute of Ophthalmology, London EC1V 9EL, UK.ORCID 0000-0003-1688-5360
German Cancer Research Center · DEThe Francis Crick Institute · GBMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Choroideremia (CHM) is an X-linked chorioretinal dystrophy leading to progressive retinal degeneration that results in blindness by late adulthood. It is caused by mutations in the

Indexed as

ChoroideremiaRetinal DystrophiesAdaptor Proteins, Signal TransducingAdultAnimalsHumansMutationPlasmidsRetinaZebrafishAdaptor Proteins, Signal TransducingCHM protein, humanchoroideremiainherited retinal diseasenon-viral gene therapyS/MAR

Identifiers

PMID37894906
PMCPMC10607001
OpenAlexW4387669115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.