Evidence map›Paper›PMID 37894795›Full record

ArticleInternational journal of molecular sciences2023

Meibomian Gland Dysfunction Is Associated with Low Levels of Immunoglobulin Chains and Cystatin-SN.

Danson Vasanthan Muttuvelu, Lasse Jørgensen Cehofski, Jeppe Holtz, Tor Paaske Utheim, Xiangjun Chen, Henrik Vorum, Steffen Heegaard, Marie Louise Roed Rasmussen, Asif Manzoor Khan, Ahmed Basim Abduljabar and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. The ILuxInternational journal of ophthalmology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Danson Vasanthan MuttuveluFaculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-4304-9704
Lasse Jørgensen CehofskiDepartment of Ophthalmology, Odense University Hospital, 5000 Odense, Denmark.ORCID 0000-0002-2150-7754
Jeppe HoltzDepartment of Ophthalmology, Odense University Hospital, 5000 Odense, Denmark.
Tor Paaske UtheimDepartment of Medical Biochemistry, Oslo University Hospital, 5000 Oslo, Norway.
Xiangjun ChenDepartment of Medical Biochemistry, Oslo University Hospital, 5000 Oslo, Norway.
Henrik VorumDepartment of Ophthalmology, Aalborg University Hospital, 9000 Aalborg, Denmark.
Steffen HeegaardDepartment of Ophthalmology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0001-5906-7670
Marie Louise Roed RasmussenDepartment of Ophthalmology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-9392-8697
Asif Manzoor KhanDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Ahmed Basim AbduljabarDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Bent HonoréDepartment of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark.ORCID 0000-0002-3459-7429
Aarhus University · DKUniversity of Copenhagen · DKOslo University Hospital · NOAalborg University Hospital · DKOdense University Hospital · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meibomian gland dysfunction (MGD) is a highly prevalent condition and the most common cause of evaporative dry eye disease. Studying the proteome of MGD can result in important advances in the management of the condition. Here, we collected tear film samples from treatment naïve patients with MGD (n = 10) and age-matched controls (n = 11) with Schirmer filtration paper. The samples were analyzed with label-free quantification nano liquid chromatography-tandem mass spectrometry. The proteins were considered differentially expressed if

Indexed as

Eyelid DiseasesMeibomian Gland DysfunctionHumansImmunoglobulinsImmunoglobulin SubunitsMeibomian GlandsSalivary CystatinsTearsCST1 protein, humanImmunoglobulinsImmunoglobulin SubunitsSalivary Cystatinsblepharitiscystatindry eyeimmunoglobulinmass spectrometrymeibomian gland dysfunctionproteomeproteomicstear

Identifiers

PMID37894795
PMCPMC10606780
OpenAlexW4387578052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.